lemborexant vs voriconazole
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Side-by-side comparison of lemborexant and voriconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Lemborexant (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Avoid concomitant use of VFEND with lemborexant.
Dayvigo
Vfend
Dayvigo is a medicine that can help you fall asleep and stay asleep. It is for adults who have trouble with insomnia.
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
Dayvigo is used to treat insomnia in adults. Insomnia means you have trouble falling asleep, staying asleep, or both. This medicine can help you sleep better.
This medicine treats several types of fungal infections. It is used for invasive aspergillosis, a lung infection. It also treats candidemia (a blood infection) and other Candida infections in the skin, abdomen, kidney, bladder, and wounds. Voriconazole can also treat esophageal candidiasis (a throat infection) and serious infections caused by Scedosporium and Fusarium fungi.
Dayvigo works by blocking orexin, a chemical in your brain that keeps you awake. By blocking orexin, Dayvigo helps you feel sleepy. This allows you to fall asleep and stay asleep.
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
- • Feeling sleepy
- • Visual disturbances
- • Fever
- • Nausea
- • Rash
- • Vomiting
- Suicide Attempt 133
- Somnolence 128
- Condition Aggravated 117
- Suicidal Ideation 115
- Fall 94
- Drug Interaction 2,315
- Death 1,460
- Pyrexia 1,411
- Pneumonia 1,321
- Condition Aggravated 1,093
Dayvigo can make you feel very sleepy, even the next day. Be careful driving or doing other things that need you to be alert. Some people have sleep paralysis, hallucinations, or do things like sleepwalking while taking Dayvigo. Dayvigo may also worsen depression or suicidal thoughts. Do not drink alcohol while taking Dayvigo.
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
It is not known if Dayvigo can harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take psychiatric medicines, including Dayvigo.
Voriconazole can cause harm to an unborn baby. If you are pregnant or could become pregnant, talk to your doctor. It is not known if voriconazole passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
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How to Read This lemborexant vs voriconazole Comparison
lemborexant is classified in the Orexin Receptor Antagonist drug class, while voriconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, lemborexant has 587 submissions while voriconazole has 7,600. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to voriconazole prevents the body from processing lemborexant correctly, which can cause the sleep medication to build up to unsafe levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for lemborexant or voriconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.