isavuconazonium vs voriconazole
Side-by-side comparison of isavuconazonium and voriconazole Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Cresemba
Vfend
Cresemba is an antifungal medicine. It is used to treat serious fungal infections in adults and children.
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
Cresemba treats invasive aspergillosis and invasive mucormycosis. These are serious infections caused by different types of fungi. Cresemba is available as an injection for those 1 year and older. Cresemba capsules are for those 6 years and older who weigh at least 35 pounds.
This medicine treats several types of fungal infections. It is used for invasive aspergillosis, a lung infection. It also treats candidemia (a blood infection) and other Candida infections in the skin, abdomen, kidney, bladder, and wounds. Voriconazole can also treat esophageal candidiasis (a throat infection) and serious infections caused by Scedosporium and Fusarium fungi.
Cresemba belongs to a class of drugs called azole antifungals. It works by stopping the growth of the fungi. This helps your body fight off the infection.
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
- • Nausea
- • Vomiting
- • Diarrhea
- • Headache
- • Changes in liver tests
- • Visual disturbances
- • Fever
- • Nausea
- • Rash
- • Vomiting
- Using the medicine for a condition it is not approved for 926
- Death 310
- Feeling sick to your stomach 143
- Fever with low white blood cell count 135
- Medicine not working 125
- The medicine is not working 4,098
- Using the medicine for a condition it is not approved for 2,342
- The medicine is interacting with another medicine 2,315
- Death 1,460
- Fever 1,411
Cresemba can cause serious liver problems. Your doctor will check your liver function before and during treatment. Cresemba can also cause allergic reactions. Tell your doctor right away if you have any signs of a reaction, like trouble breathing or skin rash. Cresemba can harm an unborn baby. Use birth control while taking this medicine.
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
Cresemba can harm your unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Do not breastfeed while taking Cresemba.
Voriconazole can cause harm to an unborn baby. If you are pregnant or could become pregnant, talk to your doctor. It is not known if voriconazole passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
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How to Read This isavuconazonium vs voriconazole Comparison
isavuconazonium is classified in the Azole Antifungal drug class, while voriconazole sits within the Azole Antifungal class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, isavuconazonium has 1,639 submissions while voriconazole has 11,626. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between isavuconazonium and voriconazole — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.