Two medicines, side by side
Fluconazole vs voriconazole
Fluconazole and voriconazole are both labeled for fungal infections. Drugs@FDA records approvals of fluconazole since 1990 and of voriconazole since 2002. Pharmacies paid $0.380 per fluconazole 200 mg tablet and $1.88 per voriconazole 200 mg tablet (NADAC, October 7, 2026).
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026); the voriconazole FDA label on DailyMed (effective February 26, 2026).
Highlights of the fluconazole record
Fluconazole (Diflucan) · label of April 7, 2026
Used for
From the label: indicationsFluconazole tablets are indicated for the treatment of: Vaginal candidiasis (vaginal yeast infections due to Candida ). Oropharyngeal and esophageal candidiasis. […]
On the market
- Earliest approval on file
- January 29, 1990
- Generic labelers
- 41 labelers
- Pharmacy cost
- $0.380 per tablet
Supply and safety
- Shortage
- No current entry
- Recalls
- 18
Highlights of the voriconazole record
Voriconazole (Vfend) · label of February 26, 2026
Used for
From the label: indicationsVFEND is an azole antifungal indicated for the treatment of adults and pediatric patients 2 years of age and older with: • Invasive aspergillosis ( 1.1 ) • Candidemia in non-neutropenics and other deep tissue Candida infections ( 1.2 ) • Esophageal candidiasis ( 1.3 ) • Serious fungal infections caused by Scedosporium apiospermum and Fusarium species including Fusarium solani, in patients intolerant of, or […]
On the market
- Earliest approval on file
- May 24, 2002
- Generic labelers
- 31 labelers
- Pharmacy cost
- $1.88 per tablet
Supply and safety
- Shortage
- A presentation being discontinued
- Recalls
- 4
Source: FDA drug labels via openFDA (Fluconazole label of April 7, 2026, Voriconazole label of February 26, 2026); NDC Directory, Drugs@FDA, NADAC, FDA shortages and recalls (October 8, 2026)
How do fluconazole and voriconazole differ on the record?
Both are in FDA's class azole antifungals.
Generics: fluconazole since 2004; voriconazole since 2010 (Drugs@FDA).
| Fluconazole | Voriconazole | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Fungal infections |
| Pharmacologic class | Azole Antifungal | Azole Antifungal |
| How it works (label) | n/a | Voriconazole is an antifungal drug [see Microbiology (12.4) ]. |
| Half-life (label) | Peak plasma concentrations (C max ) in fasted normal volunteers occur between 1 and 2 hours with a terminal plasma elimination half-life of approximately 30 hours (range: 20 to 50 hours) after oral administration. | n/a |
| Earliest approval on file (Drugs@FDA) | January 29, 1990 | May 24, 2002 |
| First generic approved | July 29, 2004 | April 22, 2010 |
| Generic labelers (NDC) | 41 labelers | 31 labelers |
| Pharmacy cost (NADAC, each one's most listed form; strengths differ) | $0.380 per tablet (Fluconazole 200 mg tablet) | $1.88 per tablet (Voriconazole 200 mg tablet) |
| 12-month price change | -10% | -2% |
| Boxed warning | No | No |
| Shortage now | No current entry | A presentation being discontinued |
| Recalls recorded | 18 | 4 |
| FAERS reports (a report is not proof of cause; counts follow how widely a medicine is used) | 69,671 | 30,201 |
| DEA schedule | none | none |
Source: Drugs@FDA, FDA NDC Directory, CMS NADAC of October 7, 2026, FDA shortages and recalls, FAERS via openFDA (FDA files October 8, 2026)
Do their labels mention each other?
Fluconazole label, drug interactionsVoriconazole Avoid concomitant administration of voriconazole and fluconazole.
Voriconazole label, drug interactionsFluconazole (CYP2C9, CYP2C19 and CYP3A4 Inhibition) Significantly Increased Avoid concomitant administration of voriconazole and fluconazole.
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by the Drug): Fluconazole (CYP2C9, CYP2C19 and CYP3A4 Inhibition); Voriconazole Plasma Exposure (C max and AUC τ after 200 mg every 12 hours): Significantly Increased; Recommendations for Voriconazole Dosage Adjustment/Comments: Avoid concomitant administration of voriconazole and fluconazole. …
Source: FDA drug labels via openFDA
What next?
- Alternatives to fluconazole
- every medicine labeled for the same conditions