ivabradine vs voriconazole
Side-by-side comparison of ivabradine and voriconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Pimozide, Quinidine, Ivabradine (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated because of potential for QT prolongation and rare occurrence of torsade de pointes.
Recommendation: Do not take these two medications together. Your doctor should find an alternative treatment to avoid serious heart risks.
Corlanor
Vfend
Ivabradine (Corlanor) is a medicine that helps lower the risk of needing to go to the hospital for worsening heart failure. It works by slowing down your heart rate.
Voriconazole (Vfend) is an antifungal medicine. It is used to treat serious fungal infections in adults and children 2 years and older.
Ivabradine is used to lower the chance of hospitalization if your heart failure gets worse. It is for adults who have stable, long-term heart failure and a weak heart (left ventricular ejection fraction ≤ 35%). You must also have a resting heart rate of 70 beats per minute or higher and are either taking the highest dose of beta-blockers you can handle or cannot take beta-blockers at all.
This medicine treats several types of fungal infections. It is used for invasive aspergillosis, a lung infection. It also treats candidemia (a blood infection) and other Candida infections in the skin, abdomen, kidney, bladder, and wounds. Voriconazole can also treat esophageal candidiasis (a throat infection) and serious infections caused by Scedosporium and Fusarium fungi.
Ivabradine works by blocking certain channels in your heart called HCN channels. These channels control your heart's natural pacemaker. By blocking these channels, ivabradine slows down your heart rate.
Voriconazole belongs to a class of drugs called azole antifungals. It works by stopping the growth of fungi. It does this by interfering with the production of the fungal cell membrane.
- • Slow heart rate
- • High blood pressure
- • Irregular heartbeat (atrial fibrillation)
- • Seeing bright flashes of light
- • Visual disturbances
- • Fever
- • Nausea
- • Rash
- • Vomiting
- Shortness of breath 459
- Low blood pressure 413
- Feeling lightheaded or unsteady 350
- Heart failure 324
- Feeling very tired 317
- The medicine is interacting with another medicine 2,315
- Death 1,460
- Fever 1,411
- Lung infection 1,322
- The condition is getting worse 1,093
Ivabradine can harm an unborn baby. If you are a woman who could get pregnant, use effective birth control while taking this medicine. This medicine can also cause a very slow heart rate. Your doctor will monitor your heart rate and adjust your dose as needed.
Voriconazole can cause serious liver problems. Your doctor will check your liver function with blood tests before and during treatment. This medicine can also cause heart rhythm problems. Make sure your potassium, magnesium, and calcium levels are normal before starting. Voriconazole can also cause severe skin reactions and make you sensitive to sunlight. Avoid sunlight and wear protective clothing. This medicine can harm an unborn baby, so women who can get pregnant should use effective birth control.
Ivabradine can cause harm to an unborn baby. Do not take this medicine if you are pregnant or planning to become pregnant. It is not recommended to breastfeed while taking ivabradine.
Voriconazole can cause harm to an unborn baby. If you are pregnant or could become pregnant, talk to your doctor. It is not known if voriconazole passes into breast milk. Talk to your doctor about the risks and benefits of breastfeeding while taking this medicine.
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How to Read This ivabradine vs voriconazole Comparison
ivabradine is classified in the HCN Channel Blocker drug class, while voriconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ivabradine has 1,863 submissions while voriconazole has 7,601. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to voriconazole stops the body from breaking down ivabradine, which can lead to dangerously high levels of the drug in the blood. this increase can cause serious and potentially life-threatening heart rhythm problems.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between ivabradine and voriconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.