dexlansoprazole vs itraconazole
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Side-by-side comparison of dexlansoprazole and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drugs Dependent on Gastric pH for Absorption (e.g., iron salts, erlotinib, dasatinib, nilotinib, mycophenolate mofetil, ketoconazole/itraconazole) Clinical Impact: Dexlansoprazole can reduce the absorption of other drugs due to its effect on reducing intragastric acidity.
Dexilant
Sporanox
Dexlansoprazole (Dexilant) is a medicine that lowers stomach acid. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
This medicine can help heal damage to your esophagus (the tube connecting your mouth to your stomach). It can also help with heartburn caused by acid reflux. Dexlansoprazole can also treat heartburn from GERD, a condition where stomach acid flows back into your esophagus.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Dexlansoprazole works by reducing the amount of acid your stomach makes. It does this by blocking a specific system in your stomach cells. This helps to heal damage caused by stomach acid.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Upper respiratory tract infection
- • Vomiting
- • Nausea
- • Rash
- • Headache
- Chronic Kidney Disease 16,100
- Acute Kidney Injury 7,791
- Renal Failure 6,721
- End Stage Renal Disease 4,842
- Renal Injury 4,339
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
Dexlansoprazole may hide signs of stomach cancer, so tell your doctor if your symptoms don't improve. It can also cause kidney problems, severe diarrhea from a Clostridium difficile infection, and bone fractures with long-term use. Some people may have severe skin reactions or lupus. Long-term use may also lead to low vitamin B12 or magnesium levels.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Based on animal studies, this medicine may harm a developing baby's bones. Talk to your doctor if you are pregnant or plan to become pregnant.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This dexlansoprazole vs itraconazole Comparison
dexlansoprazole is classified in the Proton Pump Inhibitor (PPI) drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dexlansoprazole has 39,793 submissions while itraconazole has 3,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to dexlansoprazole reduces the amount of acid in your stomach, which is necessary for itraconazole to be absorbed into your body. this can make the antifungal drug less effective at treating infections.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for dexlansoprazole or itraconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.