canagliflozin vs dapagliflozin
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of canagliflozin and dapagliflozin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Invokana
Farxiga
Invokana is a medicine used with diet and exercise to lower blood sugar in adults with type 2 diabetes. It can also help reduce the risk of heart problems and kidney disease in some patients.
Dapagliflozin (Farxiga) helps lower blood sugar in adults with type 2 diabetes. It also helps adults with heart failure or chronic kidney disease.
Invokana is used to help control blood sugar levels in adults with type 2 diabetes. It is used along with diet and exercise. Invokana can also lower the risk of major heart problems like heart attack and stroke in adults with both type 2 diabetes and heart disease. It can also reduce the risk of kidney failure, heart-related death, and hospitalization for heart failure in adults with type 2 diabetes and kidney problems.
This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure. It can also help adults with heart failure by reducing the risk of heart problems and needing urgent care for heart failure. For adults with type 2 diabetes, it can help lower the risk of needing to go to the hospital for heart failure.
Invokana is a type of medicine called an SGLT2 inhibitor. It works by preventing your kidneys from reabsorbing sugar back into your blood. This causes extra sugar to leave your body through your urine, which lowers your blood sugar levels.
Dapagliflozin is a type of medicine called an SGLT2 inhibitor. It works in the kidneys to remove extra sugar from your body through your urine. This helps to lower your blood sugar levels.
- • Yeast infections of the vagina
- • Urinary tract infection
- • Increased urination
- • Yeast infections of the vagina
- • Common cold
- • Urinary tract infections
- Diabetic Ketoacidosis 3,421
- Toe Amputation 2,195
- Osteomyelitis 2,163
- Acute Kidney Injury 1,990
- Fungal Infection 1,446
- Death 7,017
- Fatigue 2,250
- Nausea 2,218
- Dizziness 2,096
- Diarrhoea 2,074
Invokana can cause serious side effects, including: - Diabetic ketoacidosis (DKA): This is a serious condition where your body produces high levels of blood acids called ketones. DKA can be life-threatening. - Lower limb amputation: Invokana may increase your risk of needing an amputation of your foot or leg. - Volume depletion: Invokana can cause dehydration, which can lead to kidney problems and low blood pressure. - Serious infections: Invokana can increase your risk of urinary tract infections and a rare but serious infection of the tissue under the skin in the area between and around the anus and genitals (Fournier's gangrene).
Dapagliflozin can cause a serious condition called diabetic ketoacidosis (DKA), especially if you have type 1 diabetes. Symptoms include nausea, vomiting, stomach pain, and trouble breathing. If you have these symptoms, stop taking this medicine and get medical help right away. This medicine can also cause serious infections in the area between your genitals and anus. Get medical help right away if you have pain, tenderness, redness, or swelling in this area, along with a fever or feeling unwell.
Invokana is not recommended during the second and third trimesters of pregnancy because it may harm the developing baby's kidneys. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not recommended to use Invokana while breastfeeding.
This medicine may harm your unborn baby, especially during the second and third trimesters. It is not recommended while breastfeeding.
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How to Read This canagliflozin vs dapagliflozin Comparison
canagliflozin is classified in the SGLT2 Inhibitor drug class, while dapagliflozin sits within the SGLT2 Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, canagliflozin has 11,215 submissions while dapagliflozin has 15,655. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for canagliflozin or dapagliflozin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.