dapagliflozin vs ertugliflozin
Side-by-side comparison of dapagliflozin and ertugliflozin Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Farxiga
Steglatro
Dapagliflozin (Farxiga) helps lower blood sugar in adults with type 2 diabetes. It also helps adults with heart failure or chronic kidney disease.
Steglatro is a drug that combines ertugliflozin and metformin. It helps lower blood sugar in adults with type 2 diabetes, along with diet and exercise.
This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure. It can also help adults with heart failure by reducing the risk of heart problems and needing urgent care for heart failure. For adults with type 2 diabetes, it can help lower the risk of needing to go to the hospital for heart failure.
Steglatro is used to help control blood sugar levels in adults with type 2 diabetes. You should use it along with a healthy diet and regular exercise. It is not for people with type 1 diabetes.
Dapagliflozin is a type of medicine called an SGLT2 inhibitor. It works in the kidneys to remove extra sugar from your body through your urine. This helps to lower your blood sugar levels.
Steglatro contains two medicines. Ertugliflozin helps your kidneys remove sugar from your blood through urine. Metformin helps your body use insulin better and reduces sugar production in the liver.
- • Yeast infections of the vagina
- • Common cold
- • Urinary tract infections
- • Diarrhea
- • Nausea
- • Vomiting
- • Gas
- • Stomach discomfort
- Death 7,017
- Tiredness 2,250
- Feeling sick to your stomach 2,218
- Feeling lightheaded 2,096
- Loose stools 2,074
- Feeling sick to your stomach 86
- Problem with missing a dose 67
- Urinary tract infection 62
- Throwing up 59
- Fungal infection 58
Dapagliflozin can cause a serious condition called diabetic ketoacidosis (DKA), especially if you have type 1 diabetes. Symptoms include nausea, vomiting, stomach pain, and trouble breathing. If you have these symptoms, stop taking this medicine and get medical help right away. This medicine can also cause serious infections in the area between your genitals and anus. Get medical help right away if you have pain, tenderness, redness, or swelling in this area, along with a fever or feeling unwell.
Steglatro contains metformin, which can cause a serious side effect called lactic acidosis. This is a buildup of lactic acid in your blood. It can be life-threatening. Get medical help right away if you have symptoms like weakness, muscle pain, trouble breathing, stomach pain, or feel very sleepy.
This medicine may harm your unborn baby, especially during the second and third trimesters. It is not recommended while breastfeeding.
Steglatro may harm your unborn baby, especially during the second and third trimesters. Breastfeeding is not recommended while taking Steglatro. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This dapagliflozin vs ertugliflozin Comparison
dapagliflozin is classified in the SGLT2 Inhibitor drug class, while ertugliflozin sits within the SGLT2 Inhibitor class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dapagliflozin has 15,655 submissions while ertugliflozin has 332. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dapagliflozin and ertugliflozin — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.