amikacin vs omadacycline
Side-by-side comparison of amikacin and omadacycline Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Amikin
Nuzyra
Amikacin is an antibiotic medicine. It fights serious infections caused by certain types of bacteria.
Nuzyra is an antibiotic medicine. It fights certain bacteria to treat infections.
Amikacin treats serious infections caused by bacteria. This includes infections in the blood, lungs, bones, joints, brain, skin, and abdomen. It can also treat burns, post-surgery infections, and complicated urinary tract infections.
Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection. It also treats acute bacterial skin and skin structure infections (ABSSSI). Use Nuzyra only to treat infections proven or strongly suspected to be caused by bacteria. This helps reduce drug-resistant bacteria.
Amikacin belongs to a class of drugs called aminoglycosides. It works by stopping the growth of bacteria. This helps your body fight off the infection.
Nuzyra is a tetracycline antibiotic. It stops bacteria from growing by interfering with their protein production. This helps your body fight off the infection.
No common side effects listed.
- • Nausea
- • Vomiting
- • Reactions where the IV was given
- • Increased liver enzyme levels
- • High blood pressure
- Off Label Use 1,908
- Drug Ineffective 1,673
- Cough 1,620
- Dyspnoea 1,556
- Hospitalisation 1,360
- Off Label Use 405
- Nausea 245
- Vomiting 152
- Drug Ineffective 113
- Diarrhoea 107
Amikacin can potentially cause hearing loss and kidney damage. Tell your doctor if you have kidney problems or are taking other medicines that can affect your hearing or kidneys. Your doctor should closely monitor you for hearing and kidney problems during treatment. This drug can also cause muscle weakness or breathing problems, especially if you are also taking anesthesia or certain muscle relaxants.
Nuzyra may cause an imbalance in the number of deaths in patients with pneumonia. The cause of this is not known, so your doctor will watch you closely. Nuzyra can also cause tooth discoloration and affect bone growth in children under 8 and unborn babies. Diarrhea can occur, so tell your doctor if you have diarrhea while taking Nuzyra.
Tell your doctor if you are pregnant or breastfeeding. Amikacin may harm your unborn baby. It is not known if amikacin passes into breast milk.
Nuzyra can cause tooth discoloration and bone problems in unborn babies. Breastfeeding is not recommended while using Nuzyra.
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How to Read This amikacin vs omadacycline Comparison
amikacin is classified in the Aminoglycoside Antibiotic drug class, while omadacycline sits within the Tetracycline Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amikacin has 8,117 submissions while omadacycline has 1,022. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amikacin and omadacycline — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.