eravacycline vs omadacycline
Side-by-side comparison of eravacycline and omadacycline Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Xerava
Nuzyra
Xerava is an antibiotic medicine. It is used to treat complicated infections in the stomach area.
Nuzyra is an antibiotic medicine. It fights certain bacteria to treat infections.
Xerava treats complicated infections inside your belly (intra-abdominal). It works against bacteria like E. coli and Klebsiella. Xerava is only for adults 18 years and older. It is not for treating complicated urinary tract infections.
Nuzyra treats community-acquired bacterial pneumonia (CABP), a lung infection. It also treats acute bacterial skin and skin structure infections (ABSSSI). Use Nuzyra only to treat infections proven or strongly suspected to be caused by bacteria. This helps reduce drug-resistant bacteria.
Xerava is a tetracycline antibiotic. It stops bacteria from growing. This helps your body fight off the infection.
Nuzyra is a tetracycline antibiotic. It stops bacteria from growing by interfering with their protein production. This helps your body fight off the infection.
- • Reactions where the IV goes into your body
- • Feeling sick to your stomach (nausea)
- • Throwing up
- • Nausea
- • Vomiting
- • Reactions where the IV was given
- • Increased liver enzyme levels
- • High blood pressure
- Off Label Use 62
- Drug Ineffective 24
- Blood Fibrinogen Decreased 16
- Nausea 15
- Thrombocytopenia 14
- Off Label Use 405
- Nausea 245
- Vomiting 152
- Drug Ineffective 113
- Diarrhoea 107
Xerava can cause serious allergic reactions. If you are allergic to tetracycline antibiotics, you should not take Xerava. Using Xerava while teeth are developing can cause tooth discoloration. It can also slow bone growth in babies and children under 8.
Nuzyra may cause an imbalance in the number of deaths in patients with pneumonia. The cause of this is not known, so your doctor will watch you closely. Nuzyra can also cause tooth discoloration and affect bone growth in children under 8 and unborn babies. Diarrhea can occur, so tell your doctor if you have diarrhea while taking Nuzyra.
Xerava can harm an unborn baby. It can cause tooth discoloration and slow bone growth. Breastfeeding is not recommended while using Xerava.
Nuzyra can cause tooth discoloration and bone problems in unborn babies. Breastfeeding is not recommended while using Nuzyra.
Also Compare — Nearby Drugs
Compare eravacycline with
Compare omadacycline with
How to Read This eravacycline vs omadacycline Comparison
eravacycline is classified in the Tetracycline Antibiotic drug class, while omadacycline sits within the Tetracycline Antibiotic class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, eravacycline has 131 submissions while omadacycline has 1,022. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between eravacycline and omadacycline — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.