Medicines labeled for the same conditions
Alternatives to tapentadol
36 other medicines are given the same way (oral) and in the same FDA class as tapentadol or labeled mainly for the same use (pain); 19 are in its class, opioid agonists: acetaminophen and hydrocodone, oxycodone, acetaminophen and oxycodone, tramadol and 15 more; the others include 6 nonsteroidal anti-inflammatory drugs, 1 cyclooxygenase inhibitor and 1 cholinergic muscarinic antagonist (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0248 per tramadol HCl 50 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as tapentadol?
The first 24 of the 36, the same class first. Pain lists all 80 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Tapentadolopioid agonist | this medicine | 4 labelers | $14.48 per tablet 100 mg tablet | Yes | No current entry |
| Acetaminophen and hydrocodoneopioid agonist · same class | Pain | 38 labelers | $0.152 per tablet 10-325 mg tablet | Yes | No current entry |
| Oxycodoneopioid agonist · same class | Pain | 34 labelers | $0.0884 per tablet 5 mg tablet | Yes | No current entry |
| Acetaminophen and oxycodoneopioid agonist · same class | Pain | 30 labelers | $0.183 per tablet 7.5-325 mg tablet | Yes | A presentation being discontinued |
| Tramadolopioid agonist · same class | Pain | 40 labelers | $0.0248 per tablet 50 mg tablet | Yes | No current entry |
| Morphineopioid agonist · same class | Pain | 17 labelers | $0.226 per tablet 15 mg tablet | Yes | In shortage |
| Acetaminophen and codeineopioid agonist · same class | Pain | 25 labelers | $0.256 per tablet 3 tablet | Yes | No current entry |
| Hydromorphoneopioid agonist · same class | Pain | 11 labelers | $0.219 per tablet 4 mg tablet | Yes | In shortage |
| Methadoneopioid agonist · same class | Pain | 17 labelers | $0.177 per tablet 10 mg tablet | Yes | No current entry |
| Oxymorphoneopioid agonist · same class | Pain | 9 labelers | n/a | Yes | No current entry |
| Hydrocodoneopioid agonist · same class | Pain | 1 labeler | $7.95 per capsule 15 mg capsule | Yes | No current entry |
| Acetaminophen and tramadolopioid agonist · same class | Pain | 12 labelers | $0.116 per tablet 37.5-325 mg tablet | Yes | No current entry |
| Levorphanolopioid agonist · same class | Pain | 7 labelers | $10.65 per tablet 2 mg tablet | Yes | No current entry |
| Acetaminophen, butalbital, caffeine and codeinebarbiturate · same class | Pain | 5 labelers | $0.798 per capsule 50-325-40-30 mg capsule | Yes | No current entry |
| Codeineopioid agonist · same class | Pain | 1 labeler | $0.726 per tablet 30 mg tablet | Yes | No current entry |
| Hydrocodone and ibuprofenopioid agonist · same class | Pain | 2 labelers | $0.487 per unit 7.5-200 | Yes | No current entry |
| Aspirin, butalbital, caffeine and codeinebarbiturate · same class | Pain | 4 labelers | $1.00 per capsule Ascomp with codeine capsule | Yes | No current entry |
| Meperidineopioid agonist · same class | Pain | 3 labelers | $0.157 per mL 50 mg/5 mL solution | Yes | Listed; available |
| Acetaminophen and caffeine and dihydrocodeinemethylxanthine · same class | Pain | 1 labeler | n/a | Yes | No current entry |
| Aspirin and oxycodoneplatelet aggregation inhibitor · same class | Pain | 1 labeler | n/a | Yes | No current entry |
| Aspirin | Pain | none listed | $0.0142 per tablet 81 mg tablet | No | A presentation being discontinued |
| Diclofenacnonsteroidal anti-inflammatory drug | Pain | 67 labelers | $0.0619 per tablet 75 mg tablet | Yes | A presentation being discontinued |
| Phenazopyridine | Pain | none listed | $0.154 per tablet 100 mg tablet | No | No current entry |
| Etodolacnonsteroidal anti-inflammatory drug | Pain | 30 labelers | $0.262 per tablet 400 mg tablet | Yes | No current entry |
| Acetaminophen and ibuprofennonsteroidal anti-inflammatory drug | Pain | 51 labelers | $0.107 per unit 250-125 mg | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Tapentadol: the full record
- label, generics, price, shortages, recalls
- Tapentadol vs oxycodone
- two records side by side
- Tapentadol vs tramadol
- two records side by side
- Morphine vs tapentadol
- two records side by side
- Tapentadol vs hydrocodone
- two records side by side