MID-VOLUME · DEATH-HEAVY
tapentadol Side Effects
tapentadol (also sold as Nucynta) sits MID-VOLUME #180 of 524 by FAERS report count. Lead signal: DEATH-HEAVY - 62.1% of FAERS reports list death as an outcome (20,529 of 33,054). Demographics and serious-outcome tables follow.
Data updated 2026-05-15
- 33,054
- FAERS reports
FDA Adverse Event Reporting System extract for tapentadol. Stamp set CASELOAD · DEATH-HEAVY · HOSP-MID. How figures are compiled.
tapentadol: 62.1% of FAERS reports list death as an outcome (20,529 of 33,054). Caseload stamp CASELOAD; volume band MID-VOLUME #180 of 524 by FAERS report count.
Mid-book FAERS page for tapentadol (Nucynta) (33,054 reports). Signature DEATH-HEAVY. Dominant age band on file: 45-64. Educational reference only.
Counts from the openFDA FAERS extract (2005–2025). Stamps CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
DEATH leads 11,641 of 33,054 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (2,412 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (20,529 reports, 62.1%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 11,633 |
| TOXICITY TO VARIOUS AGENTS | 8,078 |
| OVERDOSE | 5,602 |
| DRUG ABUSE | 1,213 |
| ACCIDENTAL OVERDOSE | 677 |
| DRUG DEPENDENCE | 648 |
| INTENTIONAL PRODUCT MISUSE | 327 |
| COMPLETED SUICIDE | 193 |
| DRUG DIVERSION | 109 |
| DRUG INTERACTION | 95 |
| MALIGNANT NEOPLASM PROGRESSION | 70 |
| PNEUMONIA | 66 |
| NAUSEA | 53 |
| CARDIAC ARREST | 49 |
| CONFUSIONAL STATE | 42 |
| CARDIO-RESPIRATORY ARREST | 36 |
| DECREASED APPETITE | 36 |
| PNEUMONIA ASPIRATION | 36 |
| ACCIDENT | 35 |
| CONSTIPATION | 34 |
Reactions in Hospitalization Reports
Hospitalization mid-share (4,458, 13.5%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| TOXICITY TO VARIOUS AGENTS | 1,497 |
| DRUG ABUSE | 414 |
| DEATH | 332 |
| OVERDOSE | 239 |
| NAUSEA | 183 |
| PAIN | 164 |
| FALL | 151 |
| VOMITING | 150 |
| DRUG DEPENDENCE | 131 |
| SOMNOLENCE | 122 |
| ASTHENIA | 121 |
| CONFUSIONAL STATE | 121 |
| DRUG INTERACTION | 119 |
| DYSPNOEA | 116 |
| SEROTONIN SYNDROME | 112 |
| DIARRHOEA | 107 |
| PYREXIA | 103 |
| FATIGUE | 101 |
How to read tapentadol FAERS figures (CASELOAD · DEATH-HEAVY · HOSP-MID)
FAERS holds 33,054 voluntary reports linked to tapentadol (Nucynta), 2005-2025. Death is listed on 20,529 (62.1%). Hospitalization appears on 4,458 (13.5%). Top co-reported indication: Pain.
Mid-volume extract - treat DEATH-HEAVY · HOSP-MID as signal-detection rates next to 62.1% of FAERS reports list death as an outcome (20,529 of 33,054).
Read with tapentadol
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 33,247 FAERS cases (Δ 193 heavier vs tapentadol); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 32,666 FAERS cases (Δ 388 lighter vs tapentadol); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 33,477 FAERS cases (Δ 423 heavier vs tapentadol); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 33,611 FAERS cases (Δ 557 heavier vs tapentadol); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's CASELOAD · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(death_share) pole at 0.0% death-mentioned reports (Δ 62.1 pp vs tapentadol's DEATH-HEAVY): MEGA-CASE · HOSP-LIGHT.
tapentadol stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload CASELOAD and the label guide.