escitalopram vs sertraline
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of escitalopram and sertraline. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Lexapro
Zoloft
Escitalopram is a medicine used to treat depression and anxiety. It helps to balance chemicals in your brain.
Sertraline is a medicine used to treat depression and other mental health conditions. It helps balance chemicals in your brain to improve your mood and reduce anxiety.
Escitalopram is used to treat major depressive disorder (MDD) in adults and children 12 years and older. It also treats generalized anxiety disorder (GAD) in adults. This medicine can help improve your mood and reduce feelings of worry.
Sertraline is used to treat major depressive disorder in adults. This means it can help with ongoing sadness or loss of interest in things. It also treats obsessive-compulsive disorder (OCD), where you have unwanted thoughts or behaviors that you can't control. Sertraline can also treat panic disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder.
Escitalopram is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood.
Sertraline is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood, and by blocking its reabsorption, sertraline helps improve mood and reduce symptoms of depression and anxiety.
- • Trouble sleeping (insomnia)
- • Problems with ejaculation (mostly delayed ejaculation)
- • Feeling sick to your stomach (nausea)
- • Increased sweating
- • Feeling tired (fatigue)
- • Nausea
- • Diarrhea
- • Headache
- • Insomnia
- • Dizziness
- Fatigue 9,196
- Nausea 9,164
- Headache 7,114
- Diarrhoea 6,709
- Anxiety 6,447
- Nausea 6,466
- Fatigue 5,891
- Diarrhoea 5,216
- Headache 4,927
- Dizziness 4,599
Antidepressants can increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Escitalopram is not approved for use in children younger than 7 years old.
Antidepressants may increase the risk of suicidal thoughts or actions in children, teens, and young adults. Watch closely for worsening depression, unusual behavior, or thoughts of suicide. Sertraline is not approved for treating depression in children.
Tell your doctor if you are pregnant or plan to become pregnant. Taking escitalopram during pregnancy, especially later in pregnancy, may cause problems for the newborn. There is a pregnancy registry, call 1-844-405-6185.
Tell your doctor if you are pregnant or plan to become pregnant. Sertraline may affect your baby. Talk to your doctor about the risks and benefits of taking sertraline during pregnancy and breastfeeding.
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How to Read This escitalopram vs sertraline Comparison
escitalopram is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while sertraline sits within the Selective Serotonin Reuptake Inhibitor (SSRI) class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, escitalopram has 38,630 submissions while sertraline has 27,099. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for escitalopram or sertraline.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.