Medicines labeled for the same conditions
Alternatives to esomeprazole and naproxen
20 other medicines are given the same way (oral) and in the same FDA class as esomeprazole and naproxen or labeled mainly for the same use (acid reflux and ulcers); 6 are in its class, proton pump inhibitors: omeprazole, pantoprazole, lansoprazole, rabeprazole and 2 more; the others include 5 histamine-2 receptor antagonists, 1 aluminum complex and 1 dopamine-2 receptor antagonist (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0295 per omeprazole DR 20 mg capsule (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as esomeprazole and naproxen?
Acid reflux and ulcers lists all 27 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Esomeprazole and naproxenproton pump inhibitor | this medicine | 10 labelers | $1.96 per unit 500-20 mg | Yes | No current entry |
| Omeprazoleproton pump inhibitor · same class | Acid reflux and ulcers | 121 labelers | $0.0295 per capsule 20 mg capsule | No | A presentation being discontinued |
| Pantoprazoleproton pump inhibitor · same class | Acid reflux and ulcers | 52 labelers | $0.0358 per tablet 40 mg tablet | No | No current entry |
| Lansoprazoleproton pump inhibitor · same class | Acid reflux and ulcers | 59 labelers | $0.106 per capsule 30 mg capsule | No | No current entry |
| Rabeprazoleproton pump inhibitor · same class | Acid reflux and ulcers | 20 labelers | $0.224 per tablet 20 mg tablet | No | No current entry |
| Omeprazole and sodium bicarbonateproton pump inhibitor · same class | Acid reflux and ulcers | 20 labelers | $7.90 per packet 40-1,680 packet | No | No current entry |
| Dexlansoprazoleproton pump inhibitor · same class | Acid reflux and ulcers | 9 labelers | $3.71 per capsule 60 mg capsule | No | No current entry |
| Calcium carbonate | Acid reflux and ulcers | none listed | $0.0315 per tablet 750 mg tablet chewable | No | No current entry |
| Famotidinehistamine-2 receptor antagonist | Acid reflux and ulcers | 144 labelers | $0.0289 per tablet 20 mg tablet | No | No current entry |
| Sucralfatealuminum complex | Acid reflux and ulcers | 43 labelers | $0.173 per tablet 1 g tablet | No | No current entry |
| Metoclopramidedopamine-2 receptor antagonist | Acid reflux and ulcers | 28 labelers | $0.0439 per tablet 10 mg tablet | Yes | No current entry |
| Calcium carbonate and famotidine and magnesium hydroxidehistamine-2 receptor antagonist | Acid reflux and ulcers | 20 labelers | $0.258 per tablet Acid reducer complete tablet chewable | No | No current entry |
| Sodium bicarbonateosmotic laxative | Acid reflux and ulcers | none listed | $0.0128 per tablet 650 mg tablet | No | In shortage |
| Cimetidinehistamine-2 receptor antagonist | Acid reflux and ulcers | 18 labelers | $0.236 per tablet 300 mg tablet | No | No current entry |
| Magnesium oxide | Acid reflux and ulcers | none listed | $0.0346 per tablet 400 mg tablet | No | No current entry |
| Misoprostolprostaglandin e1 analog | Acid reflux and ulcers | 13 labelers | $0.719 per tablet 200 mcg tablet | Yes | No current entry |
| Ranitidinehistamine-2 receptor antagonist | Acid reflux and ulcers | 8 labelers | n/a | No | No current entry |
| Trisodium citrateanti-coagulant | Acid reflux and ulcers | none listed | n/a | No | No current entry |
| Nizatidinehistamine-2 receptor antagonist | Acid reflux and ulcers | 4 labelers | $0.804 per capsule 150 mg capsule | No | No current entry |
| Bismuth subcitrate and metronidazole and tetracyclinebismuth | Acid reflux and ulcers | 2 labelers | $2.40 per capsule 140-125-125 mg capsule | Yes | No current entry |
| Vonoprazan | Acid reflux and ulcers | none listed | $22.41 per tablet 20 mg tablet | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Esomeprazole and naproxen: the full record
- label, generics, price, shortages, recalls