Medicines labeled for the same conditions

Alternatives to diclofenac and misoprostol

20 other medicines are given the same way (oral) and in the same FDA class as diclofenac and misoprostol or labeled mainly for the same use (osteoarthritis); 16 are in its class, prostaglandin e1 analogs: ibuprofen, naproxen, celecoxib, meloxicam and 12 more; the others include 4 corticosteroids (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0166 per meloxicam 7.5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as diclofenac and misoprostol?

Osteoarthritis lists all 27 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA class	Shared indication	Generic labelers (oral)	Pharmacy cost	Boxed warning	Shortage
Diclofenac and misoprostolprostaglandin e1 analog	this medicine	10 labelers	$0.665 per tablet 50-0.2 mg tablet	Yes	No current entry
Ibuprofennonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	273 labelers	$0.0573 per tablet 800 mg tablet	Yes	No current entry
Naproxennonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	146 labelers	$0.0565 per tablet 500 mg tablet	Yes	No current entry
Celecoxibnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	65 labelers	$0.0762 per capsule 200 mg capsule	Yes	No current entry
Meloxicamnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	43 labelers	$0.0166 per tablet 7.5 mg tablet	Yes	No current entry
Etodolacnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	30 labelers	$0.262 per tablet 400 mg tablet	Yes	No current entry
Indomethacinnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	25 labelers	$0.210 per capsule 75 mg capsule	Yes	No current entry
Nabumetonenonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	28 labelers	$0.128 per tablet 500 mg tablet	Yes	No current entry
Piroxicamnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	10 labelers	$0.215 per capsule 20 mg capsule	Yes	No current entry
Famotidine and ibuprofenhistamine-2 receptor antagonist · same class	Osteoarthritis, Rheumatoid arthritis	16 labelers	$0.714 per unit 800-26.6 mg	Yes	No current entry
Sulindacnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	7 labelers	$0.189 per tablet 150 mg tablet	Yes	No current entry
Fenoprofennonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	6 labelers	n/a	Yes	No current entry
Oxaprozinnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	7 labelers	$0.475 per tablet 600 mg tablet	Yes	No current entry
Diflunisalnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	6 labelers	$1.06 per tablet 500 mg tablet	Yes	No current entry
Ketoprofennonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	5 labelers	$6.46 per capsule 200 mg capsule	Yes	No current entry
Tolmetinnonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	5 labelers	n/a	Yes	No current entry
Flurbiprofennonsteroidal anti-inflammatory drug · same class	Osteoarthritis, Rheumatoid arthritis	3 labelers	$3.17 per tablet 100 mg tablet	No	No current entry
Prednisonecorticosteroid	Osteoarthritis	46 labelers	$0.0643 per tablet 20 mg tablet	No	No current entry
Hydrocortisonecorticosteroid	Osteoarthritis	16 labelers	$0.180 per tablet 10 mg tablet	No	A presentation being discontinued
Methylprednisolonecorticosteroid	Osteoarthritis	24 labelers	$0.121 per tablet 4 mg tablet	No	In shortage
Cortisonecorticosteroid	Osteoarthritis	1 labeler	n/a	No	No current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Diclofenac and misoprostol: the full record: label, generics, price, shortages, recalls