Medicines labeled for the same conditions

Alternatives to aspirin and caffeine and orphenadrine

18 other medicines are given the same way (oral) and in the same FDA class as aspirin and caffeine and orphenadrine or labeled mainly for the same use (pain); 18 are in its class, muscle relaxants: ibuprofen, naproxen, cyclobenzaprine, celecoxib and 14 more (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0166 per meloxicam 7.5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as aspirin and caffeine and orphenadrine?

Pain lists all 80 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA class	Shared indication	Generic labelers (oral)	Pharmacy cost	Boxed warning	Shortage
Aspirin and caffeine and orphenadrinemuscle relaxant	this medicine	3 labelers	n/a	No	No current entry
Ibuprofennonsteroidal anti-inflammatory drug · same class	Pain	273 labelers	$0.0573 per tablet 800 mg tablet	Yes	No current entry
Naproxennonsteroidal anti-inflammatory drug · same class	Pain	146 labelers	$0.0565 per tablet 500 mg tablet	Yes	No current entry
Cyclobenzaprinemuscle relaxant · same class	Muscle spasms and spasticity	60 labelers	$0.0171 per tablet 10 mg tablet	No	No current entry
Celecoxibnonsteroidal anti-inflammatory drug · same class	Pain	65 labelers	$0.0762 per capsule 200 mg capsule	Yes	No current entry
Diclofenacnonsteroidal anti-inflammatory drug · same class	Pain	67 labelers	$0.0619 per tablet 75 mg tablet	Yes	A presentation being discontinued
Methocarbamolmuscle relaxant · same class	Muscle spasms and spasticity	54 labelers	$0.0395 per tablet 500 mg tablet	No	No current entry
Meloxicamnonsteroidal anti-inflammatory drug · same class	Pain	43 labelers	$0.0166 per tablet 7.5 mg tablet	Yes	No current entry
Etodolacnonsteroidal anti-inflammatory drug · same class	Pain	30 labelers	$0.262 per tablet 400 mg tablet	Yes	No current entry
Acetaminophen and ibuprofennonsteroidal anti-inflammatory drug · same class	Pain	51 labelers	$0.107 per unit 250-125 mg	Yes	No current entry
Metaxalonemuscle relaxant · same class	Muscle spasms and spasticity	33 labelers	$0.452 per tablet 800 mg tablet	No	No current entry
Carisoprodolmuscle relaxant · same class	Muscle spasms and spasticity	24 labelers	$0.0706 per tablet 350 mg tablet	No	No current entry
Ketorolaccyclooxygenase inhibitor · same class	Pain	33 labelers	$0.164 per tablet 10 mg tablet	Yes	In shortage
Chlorzoxazonemuscle relaxant · same class	Muscle spasms and spasticity	19 labelers	$0.210 per tablet 500 mg tablet	No	No current entry
Fenoprofennonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	n/a	Yes	No current entry
Diflunisalnonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	$1.06 per tablet 500 mg tablet	Yes	No current entry
Ketoprofennonsteroidal anti-inflammatory drug · same class	Pain	5 labelers	$6.46 per capsule 200 mg capsule	Yes	No current entry
Mefenamic acidnonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	$0.948 per capsule 250 mg capsule	Yes	No current entry
Hydrocodone and ibuprofenopioid agonist · same class	Pain	2 labelers	$0.487 per unit 7.5-200	Yes	No current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Aspirin and caffeine and orphenadrine: the full record: label, generics, price, shortages, recalls