Medicines labeled for the same conditions

Alternatives to aspirin, butalbital, caffeine and codeine

26 other medicines are given the same way (oral) and in the same FDA class as aspirin, butalbital, caffeine and codeine or labeled mainly for the same use (pain); 24 are in its class, barbiturates: ibuprofen, naproxen, celecoxib, acetaminophen and hydrocodone and 20 more (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0166 per meloxicam 7.5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as aspirin, butalbital, caffeine and codeine?

The first 24 of the 26, the same class first. Pain lists all 80 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA class	Shared indication	Generic labelers (oral)	Pharmacy cost	Boxed warning	Shortage
Aspirin, butalbital, caffeine and codeinebarbiturate	this medicine	4 labelers	$1.00 per capsule Ascomp with codeine capsule	Yes	No current entry
Ibuprofennonsteroidal anti-inflammatory drug · same class	Pain	273 labelers	$0.0573 per tablet 800 mg tablet	Yes	No current entry
Naproxennonsteroidal anti-inflammatory drug · same class	Pain	146 labelers	$0.0565 per tablet 500 mg tablet	Yes	No current entry
Celecoxibnonsteroidal anti-inflammatory drug · same class	Pain	65 labelers	$0.0762 per capsule 200 mg capsule	Yes	No current entry
Acetaminophen and hydrocodoneopioid agonist · same class	Pain	38 labelers	$0.152 per tablet 10-325 mg tablet	Yes	No current entry
Diclofenacnonsteroidal anti-inflammatory drug · same class	Pain	67 labelers	$0.0619 per tablet 75 mg tablet	Yes	A presentation being discontinued
Oxycodoneopioid agonist · same class	Pain	34 labelers	$0.0884 per tablet 5 mg tablet	Yes	No current entry
Meloxicamnonsteroidal anti-inflammatory drug · same class	Pain	43 labelers	$0.0166 per tablet 7.5 mg tablet	Yes	No current entry
Acetaminophen and oxycodoneopioid agonist · same class	Pain	30 labelers	$0.183 per tablet 7.5-325 mg tablet	Yes	A presentation being discontinued
Tramadolopioid agonist · same class	Pain	40 labelers	$0.0248 per tablet 50 mg tablet	Yes	No current entry
Morphineopioid agonist · same class	Pain	17 labelers	$0.226 per tablet 15 mg tablet	Yes	In shortage
Etodolacnonsteroidal anti-inflammatory drug · same class	Pain	30 labelers	$0.262 per tablet 400 mg tablet	Yes	No current entry
Acetaminophen and ibuprofennonsteroidal anti-inflammatory drug · same class	Pain	51 labelers	$0.107 per unit 250-125 mg	Yes	No current entry
Ketorolaccyclooxygenase inhibitor · same class	Pain	33 labelers	$0.164 per tablet 10 mg tablet	Yes	In shortage
Hydromorphoneopioid agonist · same class	Pain	11 labelers	$0.219 per tablet 4 mg tablet	Yes	In shortage
Methadoneopioid agonist · same class	Pain	17 labelers	$0.177 per tablet 10 mg tablet	Yes	No current entry
Oxymorphoneopioid agonist · same class	Pain	9 labelers	n/a	Yes	No current entry
Tapentadolopioid agonist · same class	Pain	4 labelers	$14.48 per tablet 100 mg tablet	Yes	No current entry
Hydrocodoneopioid agonist · same class	Pain	1 labeler	$7.95 per capsule 15 mg capsule	Yes	No current entry
Acetaminophen and tramadolopioid agonist · same class	Pain	12 labelers	$0.116 per tablet 37.5-325 mg tablet	Yes	No current entry
Fenoprofennonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	n/a	Yes	No current entry
Levorphanolopioid agonist · same class	Pain	7 labelers	$10.65 per tablet 2 mg tablet	Yes	No current entry
Diflunisalnonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	$1.06 per tablet 500 mg tablet	Yes	No current entry
Ketoprofennonsteroidal anti-inflammatory drug · same class	Pain	5 labelers	$6.46 per capsule 200 mg capsule	Yes	No current entry
Mefenamic acidnonsteroidal anti-inflammatory drug · same class	Pain	6 labelers	$0.948 per capsule 250 mg capsule	Yes	No current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Aspirin, butalbital, caffeine and codeine: the full record: label, generics, price, shortages, recalls