Zaleplon and Ibuprofen Interaction
Drug interaction information between Zaleplon and Ibuprofen.
Zaleplon and Ibuprofen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Zaleplon and Ibuprofen. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Ibuprofen can change how the kidneys filter medicine, but it does not appear to change the levels of zaleplon in the body.
What To Do
No special changes are usually needed for this combination. Your doctor may monitor your kidney health if you take these together long-term.
FDA Label Information
Drugs That Alter Renal Excretion Ibuprofen: Ibuprofen is known to affect renal function and, consequently, alter the renal excretion of other drugs. There was no apparent pharmacokinetic interaction between zaleplon and ibuprofen following single dose administration (10 mg and 600 mg, respectively) of each drug.
Zaleplon Also Interacts With
- Venlafaxine minor
- Paroxetine minor
- Warfarin minor
- Ketoconazole minor
- Carbamazepine minor
Ibuprofen Also Interacts With
- Heparin moderate
- Warfarin moderate
- Carbamazepine minor
- Digoxin minor
- Fluconazole minor
Frequently Asked Questions
Can I take Zaleplon and Ibuprofen together?
This is a minor interaction. No special changes are usually needed for this combination. Your doctor may monitor your kidney health if you take these together long-term.
How serious is the interaction between Zaleplon and Ibuprofen?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Zaleplon and Ibuprofen interact?
Ibuprofen can change how the kidneys filter medicine, but it does not appear to change the levels of zaleplon in the body.
Understanding the Zaleplon and Ibuprofen Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Zaleplon belongs to the Non-Benzodiazepine Hypnotic (Z-Drug) class and Ibuprofen belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Ibuprofen can change how the kidneys filter medicine, but it does not appear to change the levels of zaleplon in the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Zaleplon has 16 total documented interactions on file in this dataset, and Ibuprofen has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special changes are usually needed for this combination. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Zaleplon or Ibuprofen based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.