What the FDA labels say about taking them together
Ketoconazole and zaleplon
Zaleplon's FDA label of May 8, 2024 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name zaleplon. The zaleplon label: “Other strong selective CYP3A4 inhibitors such as ketoconazole can also be expected to increase the exposure of zaleplon.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the zaleplon FDA label on DailyMed (effective May 8, 2024, Aurobindo Pharma Limited).
What does the ketoconazole label say about zaleplon?
Ketoconazole's label (effective January 28, 2026) does not name zaleplon in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the zaleplon label say about ketoconazole?
Zaleplon label, drug interactionsOther strong selective CYP3A4 inhibitors such as ketoconazole can also be expected to increase the exposure of zaleplon.
Source: FDA drug label (ZALEPLON), Aurobindo Pharma Limited, effective May 8, 2024 (SPL set e092f3ca-bf44-4568-a72c-3fb2cf5b192b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Zaleplon | |
|---|---|---|
| Labeled for | Fungal infections | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $0.141 per capsule 10 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once