What the FDA labels say about taking them together
Ketoprofen and warfarin
Ketoprofen's FDA label of February 15, 2026 names warfarin in its drug interactions section, and warfarin's label names ketoprofen too. The ketoprofen label: “Warfarin The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.”
Check it at the source: the ketoprofen FDA label on DailyMed (effective February 15, 2026, Misemer Pharmaceuticals, Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the ketoprofen label say about warfarin?
Ketoprofen label, drug interactionsWarfarin The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
Source: FDA drug label (Ketoprofen), Misemer Pharmaceuticals, Inc., effective February 15, 2026 (SPL set d0f47ab6-29ff-df07-e053-2a95a90a2b51), via openFDA; the full label on DailyMed
What does the warfarin label say about ketoprofen?
Warfarin label, drug interactionsDrug Class: Nonsteroidal Anti-Inflammatory Agents; Specific Drugs: celecoxib, diclofenac, diflunisal, fenoprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, naproxen, oxaprozin, piroxicam, sulindac
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoprofen | Warfarin | |
|---|---|---|
| Labeled for | Osteoarthritis, Rheumatoid arthritis, Pain | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $6.46 per capsule 200 mg capsule | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once