Tamsulosin and Digoxin Interaction
Drug interaction information between Tamsulosin and Digoxin.
Tamsulosin and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tamsulosin and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tamsulosin does not interfere with how digoxin works or how much of it stays in your body.
FDA Label Information
7.6 Digoxin and Theophylline Dosage adjustments are not necessary when a tamsulosin hydrochloride capsules are administered concomitantly with digoxin or theophylline [see Clinical Pharmacology (12.3)].
Tamsulosin Also Interacts With
- Furosemide major
- Paroxetine moderate
- Warfarin moderate
- Erythromycin moderate
- Terbinafine moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Tamsulosin + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Tamsulosin's 18. In the minor band specifically: Tamsulosin has 9 (also Atenolol, Nifedipine, Ketoconazole, Enalapril); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Tamsulosin and Digoxin?
Tamsulosin does not interfere with how digoxin works or how much of it stays in your body.
Digoxin carries more major-labeled pairs than Tamsulosin
SPL source-record counts only. This page's band is minor · classes on file: Tamsulosin (Alpha-1 Adrenergic Blocker); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Tamsulosin's 1. This page itself is in the minor band, not the major band.
1 major · 8 moderate · 9 minor · 18 total
- Other minor peers for Tamsulosin
- Atenolol
- Nifedipine
- Ketoconazole
- Enalapril
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.