Tamoxifen and Liothyronine Interaction
Drug interaction information between Tamoxifen and Liothyronine.
Tamoxifen and Liothyronine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tamoxifen and Liothyronine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Tamoxifen increases the amount of a specific protein in your blood that carries thyroid hormone. This can change the total amount of thyroid medicine measured in your blood tests.
Tamoxifen Also Interacts With
- Warfarin major
- Anastrozole major
- Letrozole moderate
- Bupropion minor
- Desvenlafaxine minor
Liothyronine Also Interacts With
- Levothyroxine minor
- Sertraline minor
- Furosemide minor
- Propranolol minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Tamoxifen + Liothyronine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Liothyronine has 17 labeled pairs on file vs Tamoxifen's 10. In the minor band specifically: Tamoxifen has 7 (also Bupropion, Desvenlafaxine, Letrozole, Levothyroxine); Liothyronine has 17 (also Levothyroxine, Sertraline, Furosemide, Propranolol).
What mechanism field is on file for Tamoxifen and Liothyronine?
Tamoxifen increases the amount of a specific protein in your blood that carries thyroid hormone. This can change the total amount of thyroid medicine measured in your blood tests.
Tamoxifen carries more major-labeled pairs than Liothyronine
SPL source-record counts only. This page's band is minor · classes on file: Tamoxifen (Selective Estrogen Receptor Modulator (SERM)); Liothyronine (Thyroid Hormone (T3)).
Tamoxifen has 2 major-labeled pairs vs Liothyronine's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 7 minor · 10 total
- Other minor peers for Tamoxifen
- Bupropion
- Desvenlafaxine
- Letrozole
- Levothyroxine
0 major · 0 moderate · 17 minor · 17 total
- Other minor peers for Liothyronine
- Levothyroxine
- Sertraline
- Furosemide
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.