What the FDA labels say about taking them together
Phenytoin and sertraline
Phenytoin's FDA label of October 15, 2024 names sertraline in its drug interactions section, and sertraline's label names phenytoin too. The sertraline label: “Phenytoin is a narrow therapeutic index drug. ZOLOFT may increase phenytoin concentrations.”
Check it at the source: the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the phenytoin label say about sertraline?
Phenytoin label, drug interactionsInteracting Agent: Antidepressants; Examples: Fluoxetine, fluvoxamine, sertraline
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
What does the sertraline label say about phenytoin?
Sertraline label, drug interactionsPhenytoin Clinical Impact: Phenytoin is a narrow therapeutic index drug. ZOLOFT may increase phenytoin concentrations. Intervention: Monitor phenytoin levels when initiating or titrating ZOLOFT. Reduce phenytoin dosage if needed. Examples: phenytoin, fosphenytoin
Sertraline Hcl label (Almatica Pharma LLC, August 24, 2023), drug interactionsClinical Impact: Phenytoin is a narrow therapeutic index drug. Sertraline HCl Capsules may increase phenytoin concentrations. Intervention: Monitor phenytoin levels when initiating or titrating Sertraline HCl Capsules. Reduce phenytoin dosage if needed. Drugs that Prolong the QTc Interval
Source: FDA drug label (Sertraline Hcl, NDA215133), Almatica Pharma LLC, effective August 24, 2023 (SPL set 8c8bcba9-eaeb-aa44-f9ea-b580de55a439), via openFDA
Source: FDA drug label (Sertraline Hydrochloride, NDA020990), Mylan Pharmaceuticals Inc., effective September 15, 2024 (SPL set 1a58062b-e635-431a-908d-2651c6a4a21c), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Phenytoin | Sertraline | |
|---|---|---|
| Labeled for | Seizures and epilepsy | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.145 per capsule 100 mg capsule | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once