Sacubitril/Valsartan and Amiloride Interaction
Drug interaction information between Sacubitril/Valsartan and Amiloride.
Sacubitril/Valsartan and Amiloride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sacubitril/Valsartan and Amiloride. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs both prevent the body from getting rid of potassium through the urine. This can lead to a dangerous buildup of potassium in your bloodstream.
What To Do
Monitor your potassium levels closely with blood tests as directed by your healthcare provider. Tell your doctor if you use any salt substitutes or potassium-containing supplements.
FDA Label Information
7.2 Potassium-Sparing Diuretics As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium [see Warnings and Precautions (5.5)] .
Sacubitril/Valsartan Also Interacts With
- Aliskiren major
- Valsartan major
- Lithium moderate
- Spironolactone minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
Can I take Sacubitril/Valsartan and Amiloride together?
This is a minor interaction. Monitor your potassium levels closely with blood tests as directed by your healthcare provider. Tell your doctor if you use any salt substitutes or potassium-containing supplements.
How serious is the interaction between Sacubitril/Valsartan and Amiloride?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Sacubitril/Valsartan and Amiloride interact?
These drugs both prevent the body from getting rid of potassium through the urine. This can lead to a dangerous buildup of potassium in your bloodstream.
Understanding the Sacubitril/Valsartan and Amiloride Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Sacubitril/Valsartan belongs to the Neprilysin Inhibitor / ARB Combination class and Amiloride belongs to the Potassium-Sparing Diuretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs both prevent the body from getting rid of potassium through the urine. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Sacubitril/Valsartan has 5 total documented interactions on file in this dataset, and Amiloride has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Monitor your potassium levels closely with blood tests as directed by your healthcare provider. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Sacubitril/Valsartan or Amiloride based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.