amiloride vs sacubitril/valsartan
Side-by-side comparison of amiloride and sacubitril/valsartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.2 Potassium-Sparing Diuretics As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium [see Warnings and Precautions (5.5)] .
Recommendation: Monitor your potassium levels closely with blood tests as directed by your healthcare provider. Tell your doctor if you use any salt substitutes or potassium-containing supplements.
Midamor
Entresto
Amiloride is a water pill that helps your body hold onto potassium. It is often used with other water pills to prevent low potassium levels.
Entresto is a medicine that combines two drugs to help adults and children with heart failure. It helps to lower the risk of heart problems and hospital visits.
Amiloride treats high blood pressure and heart failure. It helps restore normal potassium levels if you develop low potassium while taking other water pills. It can also prevent low potassium if you are at risk, such as if you take digoxin or have heart rhythm problems. Amiloride is not usually prescribed alone.
Entresto is used to treat heart failure in adults and children aged one year and older. It is for people whose heart does not pump blood well enough. Entresto can help reduce hospital visits and the risk of death from heart problems.
Amiloride blocks sodium channels in your kidneys. This action reduces the amount of potassium lost in your urine. This helps to maintain or increase potassium levels in your body.
Entresto works by blocking a substance in your body that can worsen heart failure. It also relaxes your blood vessels, which helps your heart pump blood more easily. This combination helps to improve how well your heart works.
- • Headache
- • Nausea
- • Loss of appetite
- • Diarrhea
- • Vomiting
- • Low blood pressure
- • High potassium levels in the blood
- • Cough
- • Dizziness
- • Kidney problems
- Shortness of breath 69
- Diarrhea 57
- Feeling sick to your stomach 49
- Throwing up 39
- Tiredness 37
- Low blood pressure 11,457
- Death 9,093
- Shortness of breath 8,895
- Feeling dizzy 8,621
- Feeling tired 8,606
Amiloride can cause high potassium levels, which can be dangerous. You should not take this medicine if you already have high potassium, kidney problems, or are taking other potassium-sparing diuretics or potassium supplements. Your doctor should check your potassium levels regularly.
Entresto can harm an unborn baby, even causing death. If you are pregnant or become pregnant, stop taking Entresto right away and tell your doctor.
Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. It is not known if amiloride can harm an unborn baby or pass into breast milk.
Entresto can cause serious harm or death to an unborn baby. Do not take this medicine if you are pregnant. Breastfeeding is not recommended while taking Entresto.
How to Read This amiloride vs sacubitril/valsartan Comparison
amiloride is classified in the Potassium-Sparing Diuretic drug class, while sacubitril/valsartan sits within the Neprilysin Inhibitor / ARB Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amiloride has 251 submissions while sacubitril/valsartan has 46,672. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs both prevent the body from getting rid of potassium through the urine. this can lead to a dangerous buildup of potassium in your bloodstream.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amiloride and sacubitril/valsartan - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.