Piroxicam and Propranolol Interaction
Drug interaction information between Piroxicam and Propranolol.
Piroxicam and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Piroxicam and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This pain reliever can make your blood pressure medicine less effective and may cause kidney problems, especially in older adults.
FDA Label Information
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: •NSAIDs may diminish the antihypertensive effect of ACE inhibitors, ARBs, or beta-blockers (including propranolol).•In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.
Piroxicam Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
Frequently Asked Questions
What SPL severity band is on file for Piroxicam + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Piroxicam's 15. In the minor band specifically: Piroxicam has 11 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Piroxicam and Propranolol?
This pain reliever can make your blood pressure medicine less effective and may cause kidney problems, especially in older adults.
Propranolol's labeled portfolio outnumbers Piroxicam
SPL source-record counts only. This page's band is minor · classes on file: Piroxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Propranolol (Non-Selective Beta-Blocker).
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Piroxicam
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.