What the FDA labels say about taking them together
Phenelzine and protriptyline
Phenelzine's FDA label of June 6, 2025 names protriptyline in its warnings section; protriptyline's label does not name phenelzine itself but warns about its class (MAO inhibitors).
Check it at the source: the phenelzine FDA label on DailyMed (effective June 6, 2025, Parke-Davis Div of Pfizer Inc); the protriptyline FDA label on DailyMed (effective July 25, 2023, Epic Pharma, LLC).
What does the phenelzine label say about protriptyline?
Phenelzine label, warningsA List of Dibenzazepine Derivative Drugs by Generic Name Follows: nortriptyline hydrochloride amitriptyline hydrochloride perphenazine and amitriptyline hydrochloride clomipramine hydrochloride desipramine hydrochloride imipramine hydrochloride doxepin carbamazepine cyclobenzaprine HCl amoxapine maprotiline HCl trimipramine maleate protriptyline HCl mirtazapine NARDIL should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result.
Source: FDA drug label (Nardil), Parke-Davis Div of Pfizer Inc, effective June 6, 2025 (SPL set 513a41d0-37d4-4355-8a6d-a2c643bce6fa), via openFDA; the full label on DailyMed
What does the protriptyline label say about phenelzine?
Protriptyline's label does not name phenelzine itself; it warns about its class (MAO inhibitors):
Protriptyline label, contraindicationsWhen it is desired to substitute protriptyline for a monoamine oxidase inhibitor, a minimum of 14 days should be allowed to elapse after the latter is discontinued.
Source: FDA drug label (Protriptyline Hydrochloride), Epic Pharma, LLC, effective July 25, 2023 (SPL set c6c7c39e-e510-4f4a-bf7a-926f0e075d3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Phenelzine | Protriptyline | |
|---|---|---|
| Labeled for | n/a | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.586 per tablet 15 mg tablet | $2.71 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once