Perindopril and Digoxin Interaction
Drug interaction information between Perindopril and Digoxin.
Perindopril and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Perindopril and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Digoxin might change the levels of perindopril in your blood, although it is not yet certain how this happens.
FDA Label Information
7.5 Digoxin A controlled pharmacokinetic study has shown no effect on plasma digoxin concentrations when coadministered with perindopril erbumine, but an effect of digoxin on the plasma concentration of perindopril/perindoprilat has not been excluded.
Perindopril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Cyclosporine moderate
- Amiloride moderate
- Indomethacin moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Perindopril + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Perindopril's 9. In the minor band specifically: Perindopril has 3 (also Lithium, Gentamicin); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Perindopril and Digoxin?
Digoxin might change the levels of perindopril in your blood, although it is not yet certain how this happens.
Digoxin carries more major-labeled pairs than Perindopril
SPL source-record counts only. This page's band is minor · classes on file: Perindopril (ACE Inhibitor); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Perindopril's 1. This page itself is in the minor band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other minor peers for Perindopril
- Lithium
- Gentamicin
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.