Oxaprozin and Propranolol Interaction
Drug interaction information between Oxaprozin and Propranolol.
Oxaprozin and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxaprozin and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Oxaprozin can interfere with how propranolol works to lower your blood pressure. This happens because NSAIDs can cause the body to hold onto extra salt and water.
FDA Label Information
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of ACE inhibitors, ARBs, or beta-blockers (including propranolol).
Oxaprozin Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
Frequently Asked Questions
What SPL severity band is on file for Oxaprozin + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Oxaprozin's 15. In the minor band specifically: Oxaprozin has 11 (also Meloxicam, Aspirin, Diclofenac, Cyclosporine); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Oxaprozin and Propranolol?
Oxaprozin can interfere with how propranolol works to lower your blood pressure. This happens because NSAIDs can cause the body to hold onto extra salt and water.
Propranolol's labeled portfolio outnumbers Oxaprozin
SPL source-record counts only. This page's band is minor · classes on file: Oxaprozin (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Propranolol (Non-Selective Beta-Blocker).
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Oxaprozin
- Meloxicam
- Aspirin
- Diclofenac
- Cyclosporine
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.