What the FDA labels say about taking them together
Digoxin and oxaprozin
Oxaprozin's FDA label of December 26, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name oxaprozin. The oxaprozin label: “The concomitant use of oxaprozin with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the oxaprozin FDA label on DailyMed (effective December 26, 2024, Amneal Pharmaceuticals NY LLC).
What does the digoxin label say about oxaprozin?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name oxaprozin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the oxaprozin label say about digoxin?
Oxaprozin label, drug interactionsClinical Impact: The concomitant use of oxaprozin with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Intervention: During concomitant use of oxaprozin and digoxin, monitor serum digoxin levels.
Source: FDA drug label (Oxaprozin, NDA217927), SOLA Pharmaceuticals, LLC, effective December 3, 2025 (SPL set 450f5941-7f10-42fe-e063-6394a90a4803), via openFDA
Source: FDA drug label (Oxaprozin), Amneal Pharmaceuticals NY LLC, effective December 26, 2024 (SPL set d9b0ca6c-4c53-4f6e-918b-02a8c472a194), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Oxaprozin | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.475 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once