What the FDA labels say about taking them together
Omadacycline and tetracycline
Omadacycline's FDA label of May 27, 2026 names tetracycline in its contraindications section; the tetracycline label PlainMeds reads does not name omadacycline. The omadacycline label: “A decrease in fibula growth rate has been observed in premature infants given oral tetracycline in doses of 25 mg/kg every 6 hours.”
Check it at the source: the omadacycline FDA label on DailyMed (effective May 27, 2026, Paratek Pharmaceuticals, Inc.); the tetracycline FDA label on DailyMed (effective March 18, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the omadacycline label say about tetracycline?
Omadacycline label, contraindicationsCONTRAINDICATIONS NUZYRA is contraindicated in patients with known hypersensitivity to omadacycline or tetracycline class antibacterial drugs, or to any of the excipients [see Warnings and Precautions (5.3) and Adverse Reactions (6.1) ].
Omadacycline label, warnings and precautionsA decrease in fibula growth rate has been observed in premature infants given oral tetracycline in doses of 25 mg/kg every 6 hours.
Source: FDA drug label (NUZYRA), Paratek Pharmaceuticals, Inc., effective May 27, 2026 (SPL set 51591524-4703-44c6-8bde-dce3e6a463d1), via openFDA; the full label on DailyMed
What does the tetracycline label say about omadacycline?
Tetracycline's label (effective March 18, 2025) does not name omadacycline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (tetracycline hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective March 18, 2025 (SPL set eaa5b1bd-0927-46e4-b941-32fcc492d258), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Omadacycline | Tetracycline | |
|---|---|---|
| Labeled for | n/a | Bacterial infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.247 per capsule 250 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once