What the FDA labels say about taking them together
Olanzapine and ziprasidone
Ziprasidone's FDA label of July 20, 2026 names olanzapine in its warnings and precautions section; olanzapine's label does not name ziprasidone itself but warns about its class (Atypical antipsychotics). The ziprasidone label: “The mean increase in QTc from baseline for ziprasidone ranged from approximately 9 to 14 msec greater than for four of the comparator drugs, but was approximately 14 msec less than the prolongation observed for …”
Check it at the source: the olanzapine FDA label on DailyMed (effective March 5, 2026, Macleods Pharmaceuticals Limited); the ziprasidone FDA label on DailyMed (effective July 20, 2026, Apotex Corp.).
What does the olanzapine label say about ziprasidone?
Olanzapine's label does not name ziprasidone itself; it warns about its class (Atypical antipsychotics):
Olanzapine label, boxed warningAnalyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients.
Olanzapine label, boxed warningINCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Source: FDA drug label (Olanzapine), Macleods Pharmaceuticals Limited, effective March 5, 2026 (SPL set 8e095987-bdea-42f2-9550-c7155cf07d30), via openFDA; the full label on DailyMed
What does the ziprasidone label say about olanzapine?
Ziprasidone label, warnings and precautionsThe mean increase in QTc from baseline for ziprasidone ranged from approximately 9 to 14 msec greater than for four of the comparator drugs (risperidone, olanzapine, quetiapine, and haloperidol), but was approximately 14 msec less than the prolongation observed for thioridazine.
Source: FDA drug label (ziprasidone hydrochloride), Apotex Corp., effective July 20, 2026 (SPL set ccfd5ba2-7271-f3dd-4c98-7418c1a4b54a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Olanzapine | Ziprasidone | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | Bipolar disorder, Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.147 per tablet 20 mg tablet | $0.269 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once