Methotrexate and Adalimumab Interaction
Drug interaction information between Methotrexate and Adalimumab.
Methotrexate and Adalimumab have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methotrexate and Adalimumab. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs are often used together to treat joint pain, and methotrexate can help the body accept the other medicine better.
FDA Label Information
( 5.10 , 7.3 ) 7.1 Methotrexate Adalimumab has been studied in rheumatoid arthritis (RA) patients taking concomitant methotrexate (MTX).
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Adalimumab Also Interacts With
- Abatacept moderate
- Warfarin minor
- Cyclosporine minor
- Theophylline minor
Frequently Asked Questions
What SPL severity band is on file for Methotrexate + Adalimumab?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Adalimumab's 5. In the minor band specifically: Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin); Adalimumab has 4 (also Warfarin, Cyclosporine, Theophylline).
What mechanism field is on file for Methotrexate and Adalimumab?
These two drugs are often used together to treat joint pain, and methotrexate can help the body accept the other medicine better.
Methotrexate's labeled portfolio outnumbers Adalimumab
SPL source-record counts only. This page's band is minor · classes on file: Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)); Adalimumab (TNF-Alpha Inhibitor (Biologic)).
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Adalimumab
- Warfarin
- Cyclosporine
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.