What the FDA labels say about taking them together
Linezolid and vancomycin
Linezolid's FDA label of June 19, 2026 names vancomycin in its warnings and precautions section; the vancomycin labels PlainMeds reads (4) do not name linezolid. The linezolid label: “… imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 …”
Check it at the source: the linezolid FDA label on DailyMed (effective June 19, 2026, Hospira, Inc.); the vancomycin FDA label on DailyMed (effective June 7, 2024, Mylan Institutional LLC).
What does the linezolid label say about vancomycin?
Linezolid label, warnings and precautionsImbalance in an Investigational Study in Patients With Catheter-Related Bloodstream Infections, Including Those With Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI 0.970, 2.098].
Zyvox label (Pharmacia & Upjohn Company LLC, July 9, 2026), warnings and precautionsInform patients of the increased risk of serotonin syndrome when ZYVOX is used concomitantly with serotonergic agents. 5.4 Mortality Imbalance in an Investigational Study in Patients with Catheter-Related Bloodstream Infections, Including Those with Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI 0.970, 2.098].
Source: FDA drug label (Zyvox, NDA021131), Pharmacia & Upjohn Company LLC, effective July 9, 2026 (SPL set 3e5e9975-6f36-42e4-ab46-0e75dda83592), via openFDA
Source: FDA drug label (Linezolid), Hospira, Inc., effective June 19, 2026 (SPL set c401f1a8-cc37-461b-bfef-f2e156629bf8), via openFDA; the full label on DailyMed
What does the vancomycin label say about linezolid?
Vancomycin's label (effective June 7, 2024) and its 3 other brand-application labels do not name linezolid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Vancomycin Hydrochloride), Mylan Institutional LLC, effective June 7, 2024 (SPL set caf22ccb-df75-45ea-a1d0-ccb2d37272fb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Linezolid | Vancomycin | |
|---|---|---|
| Labeled for | Bacterial infections | Bacterial infections, Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.44 per tablet 600 mg tablet | $1.33 per capsule 125 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once