Levothyroxine and Sertraline Interaction
Drug interaction information between Levothyroxine and Sertraline.
Levothyroxine and Sertraline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levothyroxine and Sertraline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking sertraline can make your thyroid medication less effective, meaning your body might need more of it to stay healthy.
FDA Label Information
Administration of sertraline in patients stabilized on levothyroxine sodium may result in increased levothyroxine sodium requirements. Administration of sertraline in patients stabilized on levothyroxine sodium may result in increased levothyroxine sodium requirements.
Levothyroxine Also Interacts With
- Furosemide minor
- Propranolol minor
- Ferrous Sulfate minor
- Amitriptyline minor
- Carbamazepine minor
Sertraline Also Interacts With
- Clonazepam major
- Aspirin moderate
- Phenelzine moderate
- Fluoxetine minor
- Citalopram minor
Frequently Asked Questions
What SPL severity band is on file for Levothyroxine + Sertraline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sertraline has 34 labeled pairs on file vs Levothyroxine's 22. In the minor band specifically: Levothyroxine has 22 (also Furosemide, Propranolol, Ferrous Sulfate, Amitriptyline); Sertraline has 31 (also Fluoxetine, Citalopram, Paroxetine, Atenolol).
What mechanism field is on file for Levothyroxine and Sertraline?
Taking sertraline can make your thyroid medication less effective, meaning your body might need more of it to stay healthy.
Sertraline carries more major-labeled pairs than Levothyroxine
SPL source-record counts only. This page's band is minor · classes on file: Levothyroxine (Thyroid Hormone); Sertraline (Selective Serotonin Reuptake Inhibitor (SSRI)).
Sertraline has 1 major-labeled pair vs Levothyroxine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 22 minor · 22 total
- Other minor peers for Levothyroxine
- Furosemide
- Propranolol
- Ferrous Sulfate
- Amitriptyline
1 major · 2 moderate · 31 minor · 34 total
- Other minor peers for Sertraline
- Fluoxetine
- Citalopram
- Paroxetine
- Atenolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.