What the FDA labels say about taking them together
Levetiracetam and probenecid
Levetiracetam's FDA label (Levetiracetam) of March 15, 2024 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name levetiracetam. The levetiracetam label: “Renal clearance of ucb L057 in the presence of probenecid decreased 60%, probably related to competitive inhibition of tubular secretion of ucb L057.”
Check it at the source: the levetiracetam FDA label on DailyMed (effective January 28, 2026, UCB, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the levetiracetam label say about probenecid?
Levetiracetam label (Mylan Institutional LLC, March 15, 2024), drug interactionsRenal clearance of ucb L057 in the presence of probenecid decreased 60%, probably related to competitive inhibition of tubular secretion of ucb L057.
Source: FDA drug label (Levetiracetam, NDA202543), Mylan Institutional LLC, effective March 15, 2024 (SPL set 70e52e89-3844-4cd9-a406-b29e9520a12c), via openFDA
Source: FDA drug label (Keppra), NDA021505 (Ucb Inc), as published by UCB, Inc., effective January 28, 2026 (SPL set 3ca9df05-a506-4ec8-a4fe-320f1219ab21), via openFDA; the full label on DailyMed
What does the probenecid label say about levetiracetam?
Probenecid's label (effective January 5, 2021) does not name levetiracetam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levetiracetam | Probenecid | |
|---|---|---|
| Labeled for | Seizures and epilepsy | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0736 per tablet 500 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once