What the FDA labels say about taking them together
Labetalol and verapamil
Labetalol's FDA label of March 2, 2026 names verapamil in its drug interactions section; verapamil's label does not name labetalol itself but warns about its class (Beta blockers). The labetalol label: “Coadministration of labetalol HCl with non-dihydropyrindine calcium-channel antagonists (e.g., verapamil) is contraindicated.”
Check it at the source: the labetalol FDA label on DailyMed (effective March 2, 2026, Zydus Pharmaceuticals USA Inc.); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).
What does the labetalol label say about verapamil?
Labetalol label, drug interactionsCare should be taken if labetalol is used concomitantly with calcium antagonists of the verapamil type.
Labetalol Hydrochloride label (Hikma Pharmaceuticals USA Inc., December 19, 2025), contraindicationsIV administration of non-dihydropyridine calcium-channel antagonists (e.g., verapamil) Hypersensitivity reactions, including anaphylaxis, to labetalol Bronchial asthma ( 4 ) Overt cardiac failure ( 4 ) Greater-than-first-degree heart block ( 4 ) Cardiogenic shock ( 4 ) Severe bradycardia
Labetalol Hydrochloride label (Hikma Pharmaceuticals USA Inc., December 19, 2025), drug interactionsCoadministration of labetalol HCl with non-dihydropyrindine calcium-channel antagonists (e.g., verapamil) is contraindicated [see Contraindications (4) ].
Source: FDA drug label (Labetalol Hydrochloride, NDA213330), Hikma Pharmaceuticals USA Inc., effective December 19, 2025 (SPL set 99a715a0-4579-410c-b102-7ef6fab8db55), via openFDA
Source: FDA drug label (Labetalol Hydrochloride), Zydus Pharmaceuticals USA Inc., effective March 2, 2026 (SPL set 5942a5a8-c3c1-4ecb-921e-9bc92393bdf8), via openFDA; the full label on DailyMed
What does the verapamil label say about labetalol?
Verapamil's label does not name labetalol itself; it warns about its class (Beta blockers):
Verapamil label, drug interactionsAsymptomatic bradycardia (36 beats/min) with a wandering atrial pacemaker has been observed in a patient receiving concomitant timolol (a beta-adrenergic blocker) eyedrops and oral verapamil.
Verapamil label, drug interactionsVerapamil administered concomitantly with oral antihypertensive agents (e.g., vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta-blockers) will usually have an additive effect on lowering blood pressure.
Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Labetalol | Verapamil | |
|---|---|---|
| Labeled for | High blood pressure | High blood pressure, Atrial fibrillation, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.215 per tablet 300 mg tablet | $0.191 per tablet 180 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once