What the FDA labels say about taking them together
Furosemide and ketoprofen
Ketoprofen's FDA label of February 15, 2026 names furosemide in its drug interactions section; furosemide's label does not name ketoprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The ketoprofen label: “Diuretics NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.”
Check it at the source: the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC); the ketoprofen FDA label on DailyMed (effective February 15, 2026, Misemer Pharmaceuticals, Inc.).
What does the furosemide label say about ketoprofen?
Furosemide's label does not name ketoprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Furosemide label, drug interactionsThere are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
What does the ketoprofen label say about furosemide?
Ketoprofen label, drug interactionsDiuretics NSAIDs can reduce the natriuretic effect of furosemide and thiazides in some patients.
Source: FDA drug label (Ketoprofen), Misemer Pharmaceuticals, Inc., effective February 15, 2026 (SPL set d0f47ab6-29ff-df07-e053-2a95a90a2b51), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Furosemide | Ketoprofen | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Osteoarthritis, Rheumatoid arthritis, Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.490 per mL 20 mg/2 mL vial | $6.46 per capsule 200 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once