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What the FDA labels say about taking them together

Icosapent and warfarin

Icosapent's FDA label of July 9, 2026 names warfarin in its warnings and precautions section; the warfarin label PlainMeds reads does not name icosapent. The icosapent label: “The incidence of bleeding was greater in patients receiving concomitant antithrombotic medications, such as aspirin, clopidogrel, or warfarin.”

Check it at the source: the icosapent FDA label on DailyMed (effective July 9, 2026, Hikma Pharmaceuticals USA Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).

What does the icosapent label say about warfarin?

Icosapent label, warnings and precautions

The incidence of bleeding was greater in patients receiving concomitant antithrombotic medications, such as aspirin, clopidogrel, or warfarin.

Source: FDA drug label (Icosapent Ethyl), Hikma Pharmaceuticals USA Inc., effective July 9, 2026 (SPL set e3d38d1d-fbe7-413d-849a-675e7dfa9b0a), via openFDA; the full label on DailyMed

What does the warfarin label say about icosapent?

Warfarin's label (effective May 29, 2026) does not name icosapent in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

18Icosapent generic labelers
19Warfarin generic labelers
IcosapentWarfarin
Labeled forHigh triglyceridesBlood clots (DVT and PE), Atrial fibrillation
Boxed warningNoYes
Pharmacy cost (NADAC)$0.441 per capsule 1 gram capsule$0.093 per tablet 2 mg tablet
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?