Hydrochlorothiazide · more major-labeled pairs than Amiloride
SPL labels Hydrochlorothiazide + Amiloride as minor; Hydrochlorothiazide 11 / Amiloride 11 in that band.
Mechanism on file: Both medications prevent the body from releasing potassium into the urine. Taking them together increases the risk of having too much potassium in your blood.
FDA SPL severity: Minor
Hydrochlorothiazide
Full Hydrochlorothiazide label recordThiazide / Potassium-Sparing Diuretic Combination
Hydrochlorothiazide + Amiloride · SPL mechanism field
Both medications prevent the body from releasing potassium into the urine. Taking them together increases the risk of having too much potassium in your blood.
Minor band excerpt · Hydrochlorothiazide with Amiloride
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Hydrochlorothiazide · 2 major-labeled pairs (vs Amiloride's 1)
- Cholestyramine minor
- Colestipol minor
- Digoxin minor
- Eplerenone minor
Amiloride · 19 SPL pairs (broader portfolio than Hydrochlorothiazide)
- Amlodipine/Valsartan minor
- Enalapril minor
- Hydrochlorothiazide minor
- Hydrochlorothiazide/Lisinopril minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.