Eplerenone · more major-labeled pairs than Hydrochlorothiazide
SPL labels Hydrochlorothiazide + Eplerenone as minor; Hydrochlorothiazide 11 / Eplerenone 7 in that band.
Mechanism on file: These drugs work in a similar way to keep potassium in the body instead of letting it leave through urine. This can cause potassium levels to rise too high, which can affect your heart rhythm.
FDA SPL severity: Minor
Hydrochlorothiazide
Full Hydrochlorothiazide label recordThiazide / Potassium-Sparing Diuretic Combination
Hydrochlorothiazide + Eplerenone · SPL mechanism field
These drugs work in a similar way to keep potassium in the body instead of letting it leave through urine. This can cause potassium levels to rise too high, which can affect your heart rhythm.
Minor band excerpt · Hydrochlorothiazide with Eplerenone
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Hydrochlorothiazide · 13 SPL pairs (broader portfolio than Eplerenone)
- Amiloride minor
- Cholestyramine minor
- Colestipol minor
- Digoxin minor
Eplerenone · 5 major-labeled pairs (vs Hydrochlorothiazide's 2)
- Hydrochlorothiazide minor
- Hydrochlorothiazide/Lisinopril minor
- Lisinopril minor
- Lithium minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.