What the FDA labels say about taking them together
Glimepiride and probenecid
Glimepiride's FDA label of May 12, 2025 names probenecid in its drug interactions section; probenecid's label does not name glimepiride itself but warns about its class (Sulfonylureas). The glimepiride label: “… anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors.”
Check it at the source: the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the glimepiride label say about probenecid?
Glimepiride label, drug interactions… sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly protein-bound, such as fluoxetine, nonsteroidal anti-inflammatory drugs, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid and monoamine oxidase inhibitors.
Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed
What does the probenecid label say about glimepiride?
Probenecid's label does not name glimepiride itself; it warns about its class (Sulfonylureas):
Probenecid label, drug interactionsProbenecid may prolong or enhance the action of oral sulfonylureas and thereby increase the risk of hypoglycemia.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Glimepiride | Probenecid | |
|---|---|---|
| Labeled for | Type 2 diabetes | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0507 per tablet 4 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once