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What the FDA labels say about taking them together

Amphotericin b and ganciclovir

Ganciclovir's FDA label of January 9, 2026 names amphotericin b in its drug interactions section; the amphotericin b label PlainMeds reads does not name ganciclovir. The ganciclovir label: “Monitor renal function when Ganciclovir is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine.”

Check it at the source: the amphotericin b FDA label on DailyMed (effective June 3, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the ganciclovir FDA label on DailyMed (effective January 9, 2026, Fresenius Kabi USA, LLC).

What does the amphotericin b label say about ganciclovir?

Amphotericin b's label (effective June 3, 2025) does not name ganciclovir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Amphotericin B), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective June 3, 2025 (SPL set 2b2f3ff5-9d62-4ad2-8eac-1181e5911513), via openFDA; the full label on DailyMed

What does the ganciclovir label say about amphotericin b?

Ganciclovir label, drug interactions

Name of the Concomitant Drug: Cyclosporine or amphotericin B; Change in the Concentration of Ganciclovir or Concomitant Drug: Unknown; Clinical Comment: Monitor renal function when Ganciclovir is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine [see Warnings and Precautions ()].

Ganciclovir label, warnings and precautions

Increased serum creatinine levels have been reported in elderly patients and in transplant recipients receiving concomitant nephrotoxic medications (i.e., cyclosporine and amphotericin B).

Source: FDA drug label (Ganciclovir), Fresenius Kabi USA, LLC, effective January 9, 2026 (SPL set 35addab5-09db-4f8a-9c69-6fbce33ecc37), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

5Amphotericin b generic labelers
6Ganciclovir generic labelers
Amphotericin bGanciclovir
Labeled forFungal infectionsn/a
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$91.24 per gram 0.15% ophthalmic gel
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?