Ganciclovir and Amphotericin B Interaction
Drug interaction information between Ganciclovir and Amphotericin B.
Ganciclovir and Amphotericin B have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ganciclovir and Amphotericin B. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can be toxic to the kidneys when used at the same time. This combination may lead to a rise in serum creatinine levels, indicating kidney stress.
FDA Label Information
Cyclosporine or amphotericin B Unknown Monitor renal function when Ganciclovir Injection is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine [see Warnings and Precautions (5.2)]. (7) Cyclosporine or amphotericin B: When coadministered with ganciclovir, the risk of nephrotoxicity may be increased.
Ganciclovir Also Interacts With
- Cyclosporine moderate
- Trimethoprim minor
- Probenecid minor
- Bictegravir/Emtricitabine/Tenofovir minor
- Emtricitabine/Tenofovir minor
Amphotericin B Also Interacts With
- Cidofovir major
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
- Dexamethasone minor
Frequently Asked Questions
What SPL severity band is on file for Ganciclovir + Amphotericin B?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amphotericin B has 12 labeled pairs on file vs Ganciclovir's 9. In the moderate band specifically: Ganciclovir has 2 (also Cyclosporine); Amphotericin B has 2 (also Valganciclovir).
What mechanism field is on file for Ganciclovir and Amphotericin B?
Both of these medications can be toxic to the kidneys when used at the same time. This combination may lead to a rise in serum creatinine levels, indicating kidney stress.
Amphotericin B carries more major-labeled pairs than Ganciclovir
SPL source-record counts only. This page's band is moderate · classes on file: Ganciclovir (Antiviral (Nucleoside Analog)); Amphotericin B (Polyene Antifungal).
Amphotericin B has 1 major-labeled pair vs Ganciclovir's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 7 minor · 9 total
- Other moderate peers for Ganciclovir
- Cyclosporine
1 major · 2 moderate · 9 minor · 12 total
- Other moderate peers for Amphotericin B
- Valganciclovir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.