What the FDA labels say about taking them together
Furosemide and sodium zirconium cyclosilicate
Sodium zirconium cyclosilicate's FDA label of February 8, 2024 names furosemide in its drug interactions section; the furosemide labels PlainMeds reads (4) do not name sodium zirconium cyclosilicate. The sodium zirconium cyclosilicate label: “However, there was an increase in systemic exposure to weak acids such as furosemide and atorvastatin, and a decrease in systemic exposure to weak bases such as dabigatran when co-administered with LOKELMA, as shown in …”
Check it at the source: the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC); the sodium zirconium cyclosilicate FDA label on DailyMed (effective February 8, 2024, AstraZeneca Pharmaceuticals LP).
What does the furosemide label say about sodium zirconium cyclosilicate?
Furosemide's label (effective September 30, 2025) and its 3 other brand-application labels do not name sodium zirconium cyclosilicate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
What does the sodium zirconium cyclosilicate label say about furosemide?
Sodium zirconium cyclosilicate label, drug interactionsHowever, there was an increase in systemic exposure to weak acids such as furosemide and atorvastatin, and a decrease in systemic exposure to weak bases such as dabigatran when co-administered with LOKELMA, as shown in Figure 2.
Source: FDA drug label (LOKELMA), AstraZeneca Pharmaceuticals LP, effective February 8, 2024 (SPL set 90bf8e28-748d-4e4b-a19f-9cf483370eff), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Furosemide | Sodium zirconium cyclosilicate | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.490 per mL 20 mg/2 mL vial | $28.33 per packet 10 gram powder packet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once