What the FDA labels say about taking them together
Fluticasone/umeclidinium/vilanterol and formoterol
Fluticasone/umeclidinium/vilanterol's FDA label of June 2, 2023 names formoterol in its warnings and precautions section; formoterol's label does not name fluticasone/umeclidinium/vilanterol itself but warns about its class (Corticosteroids).
Check it at the source: the fluticasone/umeclidinium/vilanterol FDA label on DailyMed (effective June 2, 2023, GlaxoSmithKline LLC); the formoterol FDA label on DailyMed (effective May 31, 2019, Viatris Specialty LLC).
What does the fluticasone/umeclidinium/vilanterol label say about formoterol?
Fluticasone/umeclidinium/vilanterol label, warnings and precautionsPatients using TRELEGY ELLIPTA should not use another therapy containing a LABA (e.g., salmeterol, formoterol fumarate, arformoterol tartrate, indacaterol) for any reason.
Source: FDA drug label (Trelegy Ellipta), GlaxoSmithKline LLC, effective June 2, 2023 (SPL set b5a81d5a-4648-4c7a-951d-33c014a63c7e), via openFDA; the full label on DailyMed
What does the formoterol label say about fluticasone/umeclidinium/vilanterol?
Formoterol's label does not name fluticasone/umeclidinium/vilanterol itself; it warns about its class (Corticosteroids):
Formoterol label, contraindicationsCONTRAINDICATIONS Use of a LABA, including PERFOROMIST, without an inhaled corticosteroid is contraindicated in patients with asthma [see WARNINGS and PRECAUTIONS (5.1) ].
Formoterol label, contraindicationsUse of a LABA, including PERFOROMIST, without an inhaled corticosteroid is contraindicated in patients with asthma.
Source: FDA drug label (Perforomist), Viatris Specialty LLC, effective May 31, 2019 (SPL set fb2fe258-fe2e-47f6-8adf-ca75bf6f90af), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluticasone/umeclidinium/vilanterol | Formoterol | |
|---|---|---|
| Labeled for | COPD, Asthma | COPD |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $11.12 per unit 100-62.5-25 | $1.30 per mL 20 mcg/2 mL neb vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once