What the FDA labels say about taking them together
Ethacrynic acid and fludrocortisone
Fludrocortisone's FDA label of October 29, 2024 names ethacrynic acid in its drug interactions section; the ethacrynic acid label PlainMeds reads does not name fludrocortisone.
Check it at the source: the ethacrynic acid FDA label on DailyMed (effective August 31, 2020, Bausch Health US, LLC); the fludrocortisone FDA label on DailyMed (effective October 29, 2024, Zydus Lifesciences Limited).
What does the ethacrynic acid label say about fludrocortisone?
Ethacrynic acid's label (effective August 31, 2020) does not name fludrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (EDECRIN), Bausch Health US, LLC, effective August 31, 2020 (SPL set 1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8), via openFDA; the full label on DailyMed
What does the fludrocortisone label say about ethacrynic acid?
Fludrocortisone label, drug interactionsAmphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)–enhanced hypokalemia.
Source: FDA drug label (Fludrocortisone acetate), Zydus Lifesciences Limited, effective October 29, 2024 (SPL set 6c4a7d2d-00a4-4d80-ab4c-2afd4e4f614e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethacrynic acid | Fludrocortisone | |
|---|---|---|
| Labeled for | Edema (fluid retention), Heart failure | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.807 per tablet 25 mg tablet | $0.311 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once