What the FDA labels say about taking them together
Esomeprazole and voriconazole
Esomeprazole's FDA label of March 19, 2024 names voriconazole in its drug interactions (prescription label) section; voriconazole's label does not name esomeprazole itself but warns about its class (Proton pump inhibitors (PPIs)). The esomeprazole label: “Decreased exposure of esomeprazole when used concomitantly with strong inducers.”
Check it at the source: the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the esomeprazole label say about voriconazole?
Esomeprazole label, drug interactions (prescription label)Clinical Impact: Decreased exposure of esomeprazole when used concomitantly with strong inducers. Intervention: St. John’s Wort, rifampin: Avoid concomitant use with [see Warnings and Precautions (5.10) ]. Ritonavir-containing products: see prescribing information for specific drugs Voriconazole
Esomeprazole Strontium label (R2 Pharma, LLC, September 22, 2016), drug interactionsConcomitant administration of esomeprazole and a combined inhibitor of CYP2C19 and CYP3A4, such as voriconazole, may result in more than doubling of the esomeprazole exposure.
Source: FDA drug label (Esomeprazole Strontium, NDA202342), R2 Pharma, LLC, effective September 22, 2016 (SPL set 3c916d32-f9e9-1d15-e054-00144ff88e88), via openFDA
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
What does the voriconazole label say about esomeprazole?
Voriconazole's label does not name esomeprazole itself; it warns about its class (Proton pump inhibitors (PPIs)):
Voriconazole label, drug interactionsThe metabolism of other proton pump inhibitors that are CYP2C19 substrates may also be inhibited by voriconazole and may result in increased plasma concentrations of other proton pump inhibitors.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Esomeprazole | Voriconazole | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.145 per capsule 20 mg capsule | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once