What the FDA labels say about taking them together
Eplerenone and voriconazole
Voriconazole's FDA label of February 26, 2026 names eplerenone in its drug interactions section; the eplerenone label PlainMeds reads does not name voriconazole. The voriconazole label: “Contraindicated”
Check it at the source: the eplerenone FDA label on DailyMed (effective June 23, 2025, Viatris Specialty LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the eplerenone label say about voriconazole?
Eplerenone's label (effective June 23, 2025) does not name voriconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inspra), NDA021437 (Upjohn), as published by Viatris Specialty LLC, effective June 23, 2025 (SPL set 1a52bedc-8e2c-4116-a296-a87770676b4a), via openFDA; the full label on DailyMed
What does the voriconazole label say about eplerenone?
Voriconazole label, drug interactionsDrug/Drug Class (Mechanism of Interaction by Voriconazole): Eplerenone (CYP3A4 Inhibition); Drug Plasma Exposure (C max and AUC τ): Not Studied In Vivo or In Vitro, but Voriconazole is Likely to Significantly Increase the Plasma Concentrations of Eplerenone; Prevention or Management Recommendations: Contraindicated
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eplerenone | Voriconazole | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.308 per tablet 25 mg tablet | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once