Amitriptyline and Flecainide Interaction
Drug interaction information between Amitriptyline and Flecainide.
Amitriptyline and Flecainide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Amitriptyline and Flecainide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs compete for the same processing pathway in the liver. Because they are both handled by the same enzyme, the levels of both drugs could increase in your blood.
FDA Label Information
The drugs that inhibit cytochrome P450 2D6 include some that are not metabolized by the enzyme (quinidine; cimetidine) and many that are substrates for P450 2D6 (many other antidepressants, phenothiazines, and the Type 1C antiarrhythmics propafenone and flecainide).
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
Flecainide Also Interacts With
- Nirmatrelvir/Ritonavir major
- Darifenacin moderate
- Fluoxetine moderate
- Propranolol minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Amitriptyline + Flecainide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Flecainide has 22 labeled pairs on file vs Amitriptyline's 21. In the minor band specifically: Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Disulfiram); Flecainide has 19 (also Propranolol, Diltiazem, Nifedipine, Carbamazepine).
What mechanism field is on file for Amitriptyline and Flecainide?
These two drugs compete for the same processing pathway in the liver. Because they are both handled by the same enzyme, the levels of both drugs could increase in your blood.
Flecainide's labeled portfolio outnumbers Amitriptyline
SPL source-record counts only. This page's band is minor · classes on file: Amitriptyline (Tricyclic Antidepressant (TCA)); Flecainide (Class IC Antiarrhythmic).
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Disulfiram
1 major · 2 moderate · 19 minor · 22 total
- Other minor peers for Flecainide
- Propranolol
- Diltiazem
- Nifedipine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.