What the FDA labels say about taking them together
Digoxin and propranolol
Propranolol's FDA label (Inderal Xl) of August 27, 2026 names digoxin in its warnings and precautions section; digoxin's label does not name propranolol itself but warns about its class (Beta blockers). The propranolol label: “The concomitant use of beta-adrenergic blockers and non-dihydropyridine calcium channel blockers, digoxin or clonidine increases the risk of significant bradycardia.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the digoxin label say about propranolol?
Digoxin's label does not name propranolol itself; it warns about its class (Beta blockers):
Digoxin label, drug interactionsBeta-adrenergic blockers and calcium channel blockers Additive effects on AV node conduction can result in bradycardia and advanced or complete heart block.
Digoxin label, drug interactionsSupplements Calcium If administered rapidly by intravenous route, can produce serious arrhythmias in digitalized patients. Beta-adrenergic Blockers and Calcium Channel Blockers Additive effects on AV node conduction can result in complete heart block.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the propranolol label say about digoxin?
Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), warnings and precautionsThe concomitant use of beta-adrenergic blockers and non-dihydropyridine calcium channel blockers (e.g., verapamil and diltiazem), digoxin or clonidine increases the risk of significant bradycardia.
Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Propranolol | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once