What the FDA labels say about taking them together
Digoxin and magnesium sulfate/potassium sulfate/sodium sulfate
Magnesium sulfate/potassium sulfate/sodium sulfate's FDA label of June 30, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name magnesium sulfate/potassium sulfate/sodium sulfate. The magnesium sulfate/potassium sulfate/sodium sulfate label: “Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2 hours before and not less than 6 hours after administration of SUPREP Bowel Prep Kit to avoid …”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the magnesium sulfate/potassium sulfate/sodium sulfate FDA label on DailyMed (effective June 30, 2026, Bionpharma Inc.,).
What does the digoxin label say about magnesium sulfate/potassium sulfate/sodium sulfate?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name magnesium sulfate/potassium sulfate/sodium sulfate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the magnesium sulfate/potassium sulfate/sodium sulfate label say about digoxin?
Magnesium sulfate/potassium sulfate/sodium sulfate label, drug interactionsAdminister tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, and penicillamine at least 2 hours before and not less than 6 hours after administration of sodium sulfate, potassium sulfate, and magnesium sulfate oral solution to avoid chelation with magnesium.
Source: FDA drug label (Suprep Bowel Prep, NDA022372), Azurity Pharmaceuticals, Inc., effective January 31, 2026 (SPL set 50f23abd-6a66-44cb-960e-d43c16a5ae5f), via openFDA
Source: FDA drug label (sodium sulfate, potassium sulfate, and magnesium sulfate), Bionpharma Inc.,, effective June 30, 2026 (SPL set 31d13799-0931-7735-e063-6294a90a6d02), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Magnesium sulfate/potassium sulfate/sodium sulfate | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.0901 per mL Sod sul-potass sul-mag sul solution |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once